An association with circadian clock function and pathophysiology of aging, major depressive
disorder (MDD), and Alzheimer's disease (AD) is well established and has been proposed …

This review consolidates research employing human correlational and experimental work
across brain and body with experimental animal models to provide a more complete …

Increasing evidence suggests that disrupted temporal organization impairs behavior,
cognition, and affect; further, disruption of circadian clock genes impairs sleep–wake cycle …

Patients suffering from neuropsychiatric disorders often exhibit a loss of regulation of their
biological rhythms which leads to altered sleep/wake cycle, body temperature rhythm and …

Alzheimer's disease (AD) is a devastating and irreversible cognitive impairment and the
most common type of dementia. Along with progressive cognitive impairment, dysfunction of …

Mammalian physiology and behavior are regulated by an internal time-keeping system,
referred to as circadian rhythm. The circadian timing system has a hierarchical organization …

Circadian clock proteins form an autoregulatory feedback loop that is central to the
endogenous generation and transmission of daily rhythms in behavior and physiology …

The circadian rhythm is a nearly 24‐h oscillation found in various physiological processes in
the human brain and body that is regulated by environmental and genetic factors. It is …

Determining the cause of psychiatric disorders is a goal of modern neuroscience, and will
hopefully lead to the discovery of treatments to either prevent or alleviate the suffering …

Circadian rhythms are near 24-h cycles in a number of physiological and behavioural
parameters and the underpinning circadian timing systems is one of the key homeostatic …