Systemic inflammation and the brain: novel roles of genetic, molecular, and environmental cues as drivers of neurodegeneration

R Sankowski, S Mader… - Frontiers in cellular …, 2015 - frontiersin.org
The nervous and immune systems have evolved in parallel from the early bilaterians, in
which innate immunity and a central nervous system (CNS) coexisted for the first time, to …

The brain as a target for inflammatory processes and neuroprotective strategies

SD Skaper - Annals of the New York Academy of Sciences, 2007 - Wiley Online Library
The importance of glial cell–propagated inflammation (ie, neuroinflammation) disorders
such as Alzheimer's disease (AD) was viewed previously as a bystander effect, or …

An inflammation-centric view of neurological disease: beyond the neuron

SD Skaper, L Facci, M Zusso, P Giusti - Frontiers in cellular …, 2018 - frontiersin.org
Inflammation is a complex biological response fundamental to how the body deals with
injury and infection to eliminate the initial cause of cell injury and effect repair. Unlike a …

Current perspectives on the link between neuroinflammation and neurogenesis

B Wang, K Jin - Metabolic brain disease, 2015 - Springer
The link between neuroinflammation and neurogenesis is an area of intensive research in
contemporary neuroscience. The burgeoning amount of evidence accumulated over the …

The brain as a target of inflammation: common pathways link inflammatory and neurodegenerative diseases

F Zipp, O Aktas - Trends in neurosciences, 2006 - cell.com
Classical knowledge distinguishes between inflammatory and non-inflammatory diseases of
the brain. Either the immune system acts on the CNS and initiates a damage cascade, as in …

The role of the innate immune system in psychiatric disorders

KA Jones, C Thomsen - Molecular and Cellular Neuroscience, 2013 - Elsevier
There is by now substantial clinical evidence for an association between specific mood
disorders and altered immune function. More recently, a number of hypotheses have been …

[HTML][HTML] Neuroinflammation: ways in which the immune system affects the brain

RM Ransohoff, D Schafer, A Vincent, NE Blachère… - …, 2015 - Elsevier
Neuroinflammation is the response of the central nervous system (CNS) to disturbed
homeostasis and typifies all neurological diseases. The main reactive components of the …

Inflammation mediates varying effects in neurogenesis: relevance to the pathogenesis of brain injury and neurodegenerative disorders

NP Whitney, TM Eidem, H Peng… - Journal of …, 2009 - Wiley Online Library
Brain inflammation is a complex cellular and molecular response to stress, injury or infection
of the CNS in attempt to defend against insults, clear dead and damaged neurons and return …

Recent advances in the mechanisms of neuroinflammation and their roles in neurodegeneration

R Niranjan - Neurochemistry international, 2018 - Elsevier
Neuroinflammation is associated with the pathogenesis of many neurological disorders
including Parkinson's disease, Alzheimer's disease, Amyotrophic lateral sclerosis and …

Inflammation in CNS neurodegenerative diseases

J Stephenson, E Nutma, P van der Valk, S Amor - Immunology, 2018 - Wiley Online Library
Neurodegenerative diseases, the leading cause of morbidity and disability, are gaining
increased attention as they impose a considerable socioeconomic impact, due in part to the …