Background No proven effective medical therapy for surgery and radiation-refractory
meningiomas exists. Sunitinib malate (SU011248) is a small-molecule tyrosine kinase …

Purpose Meningiomas are the most frequently diagnosed intracranial neoplasms. Usually,
they are treated by surgical resection in curative intent. Radiotherapy and stereotactic …

Meningiomas that progress after standard therapies are challenging with limited effective
chemotherapy options. This phase II trial evaluated the efficacy of everolimus plus …

Abstract Learning Objectives After completing this course, the reader will be able to:
Evaluate patients with grade II and III meningiomas for possible implementation of adjuvant …

Intracranial meningiomas are often indolent tumors which typically grow over years to
decades. Nonetheless, meningiomas that progress after maximum safe resection and …

Atypical and anaplastic (WHO Grades II and III) meningiomas are aggressive tumors, and
patients often progress despite surgery and radiation. There is no known effective …

Purpose: Aggressive meningiomas that progress after surgery/radiotherapy represent an
unmet medical need. Strong and constant expression of SSTR2A receptors and activation of …

Object Currently, few medical options exist for refractory and atypical/anaplastic
meningiomas. New developments in chemotherapeutic options for meningiomas have been …

There are no established treatments for recurrent meningioma when surgical and radiation
options are exhausted. The epidermal growth factor receptor (EGFR) is often over …

Meningiomas are the most common primary brain tumors in adults. Most of them are benign
(World Health Organization [WHO] grade I), slow-growing lesions, but some are classified as …