The matrix metalloproteinase (MMP) family of enzymes is comprised of critically important
extracellular matrix remodeling proteases whose activity has been implicated in a number of …

A major hallmark of malignant disease is the capacity of cancer cells to cross tissue
boundaries and spread to distant sites throughout the body. Extracellular matrix-degrading …

Matrix metalloproteinases (MMPs) are a family of extracellular matrix degrading proteinases.
Owing to their matrix-degrading abilities and high expression in advanced tumors, MMPs …

Over the last years, the relevance of the matrix metalloproteinase (MMP) family in cancer
research has grown considerably. These enzymes were initially associated with the invasive …

Biomarkers are used as tools in cancer diagnostics and in treatment stratification. In most
cancers, there are increased levels of one or several members of the matrix …

Introduction• MMP‐3• MMP‐8• MMP‐9• MMP‐12• MMP‐19• MMP‐26• Conclusions The
original notion that matrix metalloproteinases (MMPs) act as tumour and metastasis …

The family of human matrix metalloproteinases (MMPs) comprises several tightly regulated
classes of proteases. These enzymes and their specific inhibitors play important roles in …

Matrix metalloproteinases have long been associated with cancer. Clinical trials of small
molecule inhibitors for this family of enzymes however, were spectacularly unsuccessful in a …

Matrix metalloproteinases (MMPs), or matrixins, are a family of zinc endopeptidases that
play a key role in both physiological and pathological tissue degradation. Normally, there is …

Tumor progression is a complex, multistage process by which a normal cell undergoes
genetic changes that result in phenotypic alterations and the acquisition of the ability to …