Safe and effective use of drugs requires an understanding of metabolism and transport. We
identified the 100 most prescribed drugs in six countries and conducted a literature search …

Membrane transporters are integral membrane proteins typically having 12 transmembrane
domains. Most of the SLC family transporters consist of 300–800 amino acid residues with a …

Drug metabolism in pharmaceutical research has traditionally focused on the well-defined
aspects of absorption, distribution, metabolism and excretion, commonly-referred to ADME …

Drug transporters are recognized as key players in the processes of drug absorption,
distribution, metabolism, and elimination. The localization of uptake and efflux transporters …

Drug transporter inhibitors are important tools to elucidate the contribution of transporters to
drug disposition both in vitro and in vivo. These inhibitors are often unselective and affect …

Metabolism alone does not adequately account for the observed intersubject variability in
drug disposition or response. Carrier-mediated processes, or transporters, are increasingly …

OBJECTIVE: To review the recent advances in knowledge about human transporters and
their effect on drug disposition. DATA SOURCES: A MEDLINE search (1996–March 2005) …

Drug transporters are expressed in many tissues such as the intestine, liver, kidney, and
brain, and play key roles in drug absorption, distribution, and excretion. The information on …

Pharmacokinetics is a branch of pharmacology that examines how drug concentrations
change with respect to time as a function of absorption, distribution, metabolism and …

Pharmacokinetic models used to describe the time course of drugs and/or metabolites in the
body and excreta are very frequently based on the assumptions that the systems are linear …