The pharmacological effects of a drug are highly dependent on the absorption, metabolism,
elimination, and distribution of the drug. In the past few years it has become apparent that …

ABSTRACT P‐glycoprotein (P‐gp)‐based drug interactions are a major concern in the clinic
and in preclinical drug development, especially with respect to the intestinal absorption of …

The ATP‐binding cassette transporter P‐glycoprotein is now recognized as an important
determinant for disposition of multiple drugs. The use of P‐glycoprotein‐expressing cell …

Drug transporters are now increasingly recognized as important determinants of variable
drug disposition and response. In addition, transporter associated problems appear to be …

Transport proteins expressed in the different barriers of the human body can have great
implications on absorption, distribution, and excretion of drug compounds. Inhibition or …

P-glycoprotein, the most extensively studied ATP-binding cassette (ABC) transporter,
functions as a biological barrier by extruding toxins and xenobiotics out of cells. In vitro and …

Abstract P‐glycoprotein (P‐gp) is a transporter protein that is come under the ATP binding
cassette family of proteins. It is situated on the surface of the intestine epithelium, where P …

The ATP-dependent drug efflux pump P-glycoprotein (P-gp) affects the absorption and
disposition of many compounds. P-gp may also play role in clinically significant drug− drug …

Permeability-glycoprotein (Pgp) is a drug transporter responsible for the efflux of xenobiotics
out of cells that influence the pharmacokinetics of numerous drugs. However, the role of this …

Understanding transporter-mediated drug–drug interactions (DDIs) for investigational
agents is important during drug development to assess DDI liability, its clinical relevance …