[HTML][HTML] Complement C3aR inactivation attenuates tau pathology and reverses an immune network deregulated in tauopathy models and Alzheimer's disease

A Litvinchuk, YW Wan, DB Swartzlander, F Chen… - Neuron, 2018 - cell.com
Strong evidence implicates the complement pathway as an important contributor to amyloid
pathology in Alzheimer's disease (AD); however, the role of complement in tau modulation …

[HTML][HTML] Complement C3 is activated in human AD brain and is required for neurodegeneration in mouse models of amyloidosis and tauopathy

T Wu, B Dejanovic, VD Gandham, A Gogineni… - Cell reports, 2019 - cell.com
Complement pathway overactivation can lead to neuronal damage in various neurological
diseases. Although Alzheimer's disease (AD) is characterized by β-amyloid plaques and tau …

Astrocyte-microglia cross talk through complement activation modulates amyloid pathology in mouse models of Alzheimer's disease

H Lian, A Litvinchuk, ACA Chiang… - Journal of …, 2016 - Soc Neuroscience
Increasing evidence supports a role of neuroinflammation in the pathogenesis of
Alzheimer's disease (AD). Previously, we identified a neuron–glia signaling pathway …

Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice

Q Shi, S Chowdhury, R Ma, KX Le, S Hong… - Science translational …, 2017 - science.org
The complement cascade not only is an innate immune response that enables removal of
pathogens but also plays an important role in microglia-mediated synaptic refinement during …

Treatment with a C5aR antagonist decreases pathology and enhances behavioral performance in murine models of Alzheimer's disease

MI Fonseca, RR Ager, SH Chu, O Yazan… - The Journal of …, 2009 - journals.aai.org
Alzheimer's disease (AD) is an age-related dementia, characterized by amyloid plaques,
neurofibrillary tangles, neuroinflammation, and neuronal loss in the brain. Components of …

[HTML][HTML] NFκB-activated astroglial release of complement C3 compromises neuronal morphology and function associated with Alzheimer's disease

H Lian, L Yang, A Cole, L Sun, ACA Chiang… - Neuron, 2015 - cell.com
Abnormal NFκB activation has been implicated in Alzheimer's disease (AD). However, the
signaling pathways governing NFκB regulation and function in the brain are poorly …

Complement-mediated events in Alzheimer's disease: mechanisms and potential therapeutic targets

AJ Tenner - The Journal of Immunology, 2020 - journals.aai.org
An estimated 5.7 million Americans suffer from Alzheimer's disease in the United States, with
no disease-modifying treatments to prevent or treat cognitive deficits associated with the …

[HTML][HTML] Complement C1q-dependent excitatory and inhibitory synapse elimination by astrocytes and microglia in Alzheimer's disease mouse models

B Dejanovic, T Wu, MC Tsai, D Graykowski… - Nature Aging, 2022 - nature.com
Microglia and complement can mediate neurodegeneration in Alzheimer's disease (AD). By
integrative multi-omics analysis, here we show that astrocytic and microglial proteins are …

[HTML][HTML] Prevention of C5aR1 signaling delays microglial inflammatory polarization, favors clearance pathways and suppresses cognitive loss

MX Hernandez, S Jiang, TA Cole, SH Chu… - Molecular …, 2017 - Springer
Background Pharmacologic inhibition of C5aR1, a receptor for the complement activation
proinflammatory fragment, C5a, suppressed pathology and cognitive deficits in Alzheimer's …

Tau pathology epigenetically remodels the neuron-glial cross-talk in Alzheimer's disease

LT Zhou, D Liu, HC Kang, L Lu, HZ Huang, WQ Ai… - Science …, 2023 - science.org
The neuron-glia cross-talk is critical to brain homeostasis and is particularly affected by
neurodegenerative diseases. How neurons manipulate the neuron-astrocyte interaction …