State-dependent inhibition of TRPM2 channel by acidic pH
Transient receptor potential melastatin 2 (TRPM2) channel fulfills an important role in
oxidative stress signaling in immune and other cells, to which local extracellular acidosis is …
oxidative stress signaling in immune and other cells, to which local extracellular acidosis is …
Modulation of TRPM2 by acidic pH and the underlying mechanisms for pH sensitivity
TRPM2 is a Ca2+-permeable nonselective cation channel that plays important roles in
oxidative stress–mediated cell death and inflammation processes. However, how TRPM2 is …
oxidative stress–mediated cell death and inflammation processes. However, how TRPM2 is …
Inactivation of TRPM2 channels by extracellular divalent copper
W Yu, LH Jiang, Y Zheng, X Hu, J Luo, W Yang - PLoS One, 2014 - journals.plos.org
Cu2+ is an essential metal ion that plays a critical role in the regulation of a number of ion
channels and receptors in addition to acting as a cofactor in a variety of enzymes. Here, we …
channels and receptors in addition to acting as a cofactor in a variety of enzymes. Here, we …
Negatively charged amino acids near and in transient receptor potential (TRP) domain of TRPM4 channel are one determinant of its Ca2+ sensitivity
S Yamaguchi, A Tanimoto, K Otsuguro, H Hibino… - Journal of Biological …, 2014 - ASBMB
Transient receptor potential (TRP) channel melastatin subfamily member 4 (TRPM4) is a
broadly expressed nonselective monovalent cation channel. TRPM4 is activated by …
broadly expressed nonselective monovalent cation channel. TRPM4 is activated by …
Putative chanzyme activity of TRPM2 cation channel is unrelated to pore gating
B Tóth, I Iordanov, L Csanády - Proceedings of the National …, 2014 - National Acad Sciences
Transient receptor potential melastatin 2 (TRPM2) is a Ca2+-permeable cation channel
expressed in immune cells of phagocytic lineage, pancreatic β cells, and brain neurons and …
expressed in immune cells of phagocytic lineage, pancreatic β cells, and brain neurons and …
Identification of direct and indirect effectors of the transient receptor potential melastatin 2 (TRPM2) cation channel
B Tóth, L Csanády - Journal of Biological Chemistry, 2010 - ASBMB
Transient receptor potential melastatin 2 (TRPM2) is a Ca 2+-permeable cation channel
involved in physiological and pathophysiological processes linked to oxidative stress …
involved in physiological and pathophysiological processes linked to oxidative stress …
Conserved cysteine residues in the pore region are obligatory for human TRPM2 channel function
ZZ Mei, HJ Mao, LH Jiang - American Journal of Physiology …, 2006 - journals.physiology.org
TRPM2 proteins belong to the melastatin-related transient receptor potential or TRPM
subfamily and form Ca2+-permeable cationic channels activated by intracellular adenosine …
subfamily and form Ca2+-permeable cationic channels activated by intracellular adenosine …
Intracellular calcium activates TRPM2 and its alternative spliced isoforms
Melastatin-related transient receptor potential channel 2 (TRPM2) is a Ca2+-permeable,
nonselective cation channel that is involved in oxidative stress-induced cell death and …
nonselective cation channel that is involved in oxidative stress-induced cell death and …
Four Ca2+ Ions Activate TRPM2 Channels by Binding in Deep Crevices near the Pore but Intracellularly of the Gate
L Csanády, B Törőcsik - Journal of General Physiology, 2009 - rupress.org
TRPM2 is a tetrameric Ca2+-permeable channel involved in immunocyte respiratory burst
and in postischaemic neuronal death. In whole cells, TRPM2 activity requires intracellular …
and in postischaemic neuronal death. In whole cells, TRPM2 activity requires intracellular …
TRPM2 Channel-Mediated ROS-Sensitive Ca2+ Signaling Mechanisms in Immune Cells
SA Syed Mortadza, L Wang, D Li, LH Jiang - Frontiers in immunology, 2015 - frontiersin.org
Transient receptor potential melastatin 2 (TRPM2) proteins form Ca2+-permeable cationic
channels that are potently activated by reactive oxygen species (ROS). ROS are produced …
channels that are potently activated by reactive oxygen species (ROS). ROS are produced …