State-dependent inhibition of TRPM2 channel by acidic pH

W Yang, J Zou, R Xia, ML Vaal, VA Seymour… - Journal of Biological …, 2010 - ASBMB
Transient receptor potential melastatin 2 (TRPM2) channel fulfills an important role in
oxidative stress signaling in immune and other cells, to which local extracellular acidosis is …

Modulation of TRPM2 by acidic pH and the underlying mechanisms for pH sensitivity

J Du, J Xie, L Yue - Journal of General Physiology, 2009 - rupress.org
TRPM2 is a Ca2+-permeable nonselective cation channel that plays important roles in
oxidative stress–mediated cell death and inflammation processes. However, how TRPM2 is …

Inactivation of TRPM2 channels by extracellular divalent copper

W Yu, LH Jiang, Y Zheng, X Hu, J Luo, W Yang - PLoS One, 2014 - journals.plos.org
Cu2+ is an essential metal ion that plays a critical role in the regulation of a number of ion
channels and receptors in addition to acting as a cofactor in a variety of enzymes. Here, we …

Negatively charged amino acids near and in transient receptor potential (TRP) domain of TRPM4 channel are one determinant of its Ca2+ sensitivity

S Yamaguchi, A Tanimoto, K Otsuguro, H Hibino… - Journal of Biological …, 2014 - ASBMB
Transient receptor potential (TRP) channel melastatin subfamily member 4 (TRPM4) is a
broadly expressed nonselective monovalent cation channel. TRPM4 is activated by …

Putative chanzyme activity of TRPM2 cation channel is unrelated to pore gating

B Tóth, I Iordanov, L Csanády - Proceedings of the National …, 2014 - National Acad Sciences
Transient receptor potential melastatin 2 (TRPM2) is a Ca2+-permeable cation channel
expressed in immune cells of phagocytic lineage, pancreatic β cells, and brain neurons and …

Identification of direct and indirect effectors of the transient receptor potential melastatin 2 (TRPM2) cation channel

B Tóth, L Csanády - Journal of Biological Chemistry, 2010 - ASBMB
Transient receptor potential melastatin 2 (TRPM2) is a Ca 2+-permeable cation channel
involved in physiological and pathophysiological processes linked to oxidative stress …

Conserved cysteine residues in the pore region are obligatory for human TRPM2 channel function

ZZ Mei, HJ Mao, LH Jiang - American Journal of Physiology …, 2006 - journals.physiology.org
TRPM2 proteins belong to the melastatin-related transient receptor potential or TRPM
subfamily and form Ca2+-permeable cationic channels activated by intracellular adenosine …

Intracellular calcium activates TRPM2 and its alternative spliced isoforms

J Du, J Xie, L Yue - Proceedings of the National Academy of …, 2009 - National Acad Sciences
Melastatin-related transient receptor potential channel 2 (TRPM2) is a Ca2+-permeable,
nonselective cation channel that is involved in oxidative stress-induced cell death and …

Four Ca2+ Ions Activate TRPM2 Channels by Binding in Deep Crevices near the Pore but Intracellularly of the Gate

L Csanády, B Törőcsik - Journal of General Physiology, 2009 - rupress.org
TRPM2 is a tetrameric Ca2+-permeable channel involved in immunocyte respiratory burst
and in postischaemic neuronal death. In whole cells, TRPM2 activity requires intracellular …

TRPM2 Channel-Mediated ROS-Sensitive Ca2+ Signaling Mechanisms in Immune Cells

SA Syed Mortadza, L Wang, D Li, LH Jiang - Frontiers in immunology, 2015 - frontiersin.org
Transient receptor potential melastatin 2 (TRPM2) proteins form Ca2+-permeable cationic
channels that are potently activated by reactive oxygen species (ROS). ROS are produced …