Background Relationships between improvements in lung function and other clinical
outcomes in chronic obstructive pulmonary disease (COPD) are not documented …

The association between clinically relevant changes in patient-reported outcomes (PROs)
and forced expiratory volume in 1 s (FEV1) in patients with chronic obstructive pulmonary …

Given the heterogeneity of chronic obstructive pulmonary disease (COPD), personalized
clinical management is key to optimizing patient outcomes. Important treatment goals …

Background Exacerbations affect morbidity in chronic obstructive pulmonary disease
(COPD). We sought to evaluate the association between exacerbation frequency and …

The change in FEV1 has been the traditional metric used to define the progression of
chronic obstructive pulmonary disease in affected patients. Consequently, various …

Background Estimates for lung function decline in chronic obstructive pulmonary disease
(COPD) have differed by study setting and have not been described in a UK primary care …

Rationale: Whether pharmacological therapy alters decline in FEV1 in chronic obstructive
pulmonary disease remains controversial. Because pharmacotherapy improves health …

The decline in lung function over time is a fundamental measure of disease progression
among patients with chronic obstructive pulmonary disease (COPD). As a result, forced …

Background COPD exacerbations are associated with accelerated lung function decline, but
whether they are causal is unknown. We evaluated the effect of a single exacerbation on …

Purpose Real-world evidence on the impact of forced expiratory volume in one second
(FEV1) and exacerbations on health-related quality of life (HRQoL) in patients with chronic …