In the present study, we report our findings on the impact of p53 disruption on the sensitivity
of human cell lines to the antimitotic agents Taxol and vincristine. Comparisons of cell …

The efficacy of chemotherapeutic agents may be determined by a number of different factors,
including the genotype of the tumor cell. The p53 tumor suppressor gene frequently is …

The effective dose, schedule, molecular basis of the cytotoxicity of taxol and their
dependence on the genetic background in tumor cells are still not well understood. Here, we …

With the use of clonogenic survival assays, we show that wild-type p53-expressing A2780
human ovarian cell lines transfected with a dominant negative mutant p53 gene (codon 143 …

The possibility that appropriately designed chemotherapy could act selectively against p53-
defective tumor cells was explored in MCF-7 human breast cancer cells. These cells were …

One of the mechanisms in which anticancer therapies function is to induce cell death by
apoptosis. In this regard, the biological activity of p53 may be critical since the presence of …

The present study assessed the role of the p53 tumor suppressor gene in cell cycle arrest
and apoptosis following treatment of Burkitt's lymphoma and lymphoblastoid cell lines with γ …

HL-60 cells that stably express transfected wild-type (wt) p53 were used to determine
whether restoration of wt p53 increased the chemosensitivity of cells that normally lack p53 …

A stable transfectant (S2SN7) of p53-null SaOS-2 (human osteosarcoma) cells expressing
wild-type p53 under the tight control of a tetracycline-responsive promoter was used to study …

Posttranslational modifications of p53 induced by two widely used anticancer agents,
cisplatinum (DDP) and taxol were investigated in two human cancer cell lines. Although both …