The signaling processes that maintain the homeostatic proliferation of peripheral T-cells and
result in their self-renewal largely remain to be elucidated. Much focus has been placed on …

IL-7 is well known as a lymphopoietic cytokine, but recent studies have also identified a
critical role for IL-7 in peripheral T cell homeostasis. IL-7 is well poised to serve as a …

Interleukin-7 (IL-7) is an essential cytokine for T cells. However, IL-7 is not produced by T
cells themselves such that T cells are dependent on extrinsic IL-7. In fact, in the absence of …

Interleukin-7 (IL-7), a molecule known for its growth-promoting effects on progenitors of B
cells, remains one of the most extensively studied cytokines. It plays a vital role in health …

Abstract Interleukin-7 (IL-7) is required for T cell development and for maintaining and
restoring homeostasis of mature T cells. IL-7 is a limiting resource under normal conditions …

Interleukin-7 (IL-7) is a cytokine produced predominantly by stromal cells of the thymus and
bone marrow and is essential for lymphopoiesis. This paper reviews the importance of IL-7 …

The development and homeostasis of adaptive and innate lymphocytes is dependent on the
stromal cytokine IL-7. The initial priming of immune responses to pathogenic challenges is …

Interleukin-7 (IL-7), a product of stromal cells, provides critical signals to lymphoid cells at
early stages in their development. Two types of cellular responses to IL-7 have been …

The thymus is the birthplace of all T lineage cells. But the thymus is also a cradle as it
provides the environment for further maturation and differentiation of immature thymocytes …

The cytokine IL-7 and its receptor, IL-7R, are critical for T cell and, in the mouse, B cell
development, as well as differentiation and survival of naive T cells, and generation and …