Context Although off-label medications are frequently prescribed in palliative care, there are
no published studies examining their use in the US Objectives We examined the frequency …

Background: Off-label-use is an indispensable element of palliative medicine. Up to one
third of all drugs are prescribed beyond their licence. It is challenging to find the right …

Off-label prescription is part of routine care in palliative medicine, but no information is
available about the situation in Italy. A cross-sectional observational survey was undertaken …

Background: Drug use beyond the licence (off-label use, off-label drug use) is a common
practice in palliative care and respective recommendations can often be identified in the …

Background: Regulatory bodies including the European Medicines Agency register
medications (formulation, route of administration) for specific clinical indications. Once …

Background: The 'off-label'use of a drug beyond the specifications of its Marketing
Authorization is widespread in palliative care. It is legal, but there are implications for …

Off-label prescribing occurs when a practitioner prescribes a drug for a use, or in a manner,
not listed in the 'approved product information'(API) for that drug. The literature suggests that …

Purpose The decision-making process for medication use in the last weeks of life is complex
because of patient frailty and poor prognosis. Limited literature is available on medication …

Background In end-of-life care, symptoms of discomfort are mainly managed by drug
therapy, the guidelines for which are mainly based on expert opinions. A few papers have …

Objectives The use of drugs beyond their marketing authorisation, that is, off-label use, is
common practice in palliative care with over 70% of off-label use having little or no scientific …