Diabetes-induced damage to peripheral nerve culminates in development of peripheral
diabetic neuropathy (PDN), one of the most devastating complications of diabetes mellitus …

Peripheral diabetic neuropathy (PDN) affects up to 60% to 70% of diabetic patients, and is
the leading cause of foot amputation. The pathogenesisof PDN involves multiple …

Neuropathies of the peripheral and autonomic nervous systems affect up to half of all people
with diabetes, and are major risk factors for foot ulceration and amputation. The aetiology is …

The prevalence of diabetes has reached epidemic proportions. There are two forms of
diabetes: type 1 diabetes mellitus is due to auto-immune-mediated destruction of pancreatic …

Diabetic neuropathy is a neuro-degenerative disorder that encompasses numerous factors
that impact peripheral nerves in the context of diabetes mellitus (DM). Diabetic peripheral …

Neuropathy is the most common complication of diabetes. As a consequence of
longstanding hyperglycemia, a downstream metabolic cascade leads to peripheral nerve …

The Diabetes Control and Complications Trial (DCCT) established the importance of
hyperglyemia and other consequences of insulin deficiency in the pathogenesis of diabetic …

Diabetic peripheral neuropathy (DPN) is a common complication affecting more than one
third of diabetes mellitus (DM) patients. Although all cellular components participating in …

Diabetic polyneuropathy (DPN) continues to be generally considered as a “microvascular”
complication of diabetes mellitus alongside nephropathy and retinopathy. The microvascular …

Diabetic neuropathy is one of the clinical syndromes characterized by pain and substantial
morbidity primarily due to a lesion of the somatosensory nervous system. The burden of …