Background Targeted preventive therapy for individuals at highest risk of incident
tuberculosis might impact the epidemic by interrupting transmission. We tested performance …

Background A rapid, blood-based triage test that allows targeted investigation for
tuberculosis at the point of care could shorten the time to tuberculosis treatment and reduce …

Background The highest risk of tuberculosis arises in the first few months after exposure. We
reasoned that this risk reflects incipient disease among tuberculosis contacts. Blood …

The risk of tuberculosis (TB) is variable among individuals with latent Mycobacterium
tuberculosis infection (LTBI), but validated estimates of personalized risk are lacking. In …

Background Tackling tuberculosis requires testing and treatment of latent tuberculosis in
high-risk groups. The aim of this study was to estimate the predictive values of the tuberculin …

Background Contacts of tuberculosis index cases are at increased risk of developing
tuberculosis. Screening, preventive therapy, and surveillance for tuberculosis are underused …

Biomarkers are indispensable to the development of new tuberculosis therapeutics and
vaccines. The most robust biomarkers measure factors that are essential to the underlying …

The billions of people with latent tuberculosis infection serve as the seedbeds for future
cases of active tuberculosis. Virtually all episodes of tuberculosis disease are preceded by a …

Improved tuberculosis diagnostics and tools for monitoring treatment response are urgently
needed. We developed a robust and simple, PCR-based host-blood transcriptomic …

New approaches to control the spread of tuberculosis (TB) are needed, including tools to
predict development of active TB from latent TB infection (LTBI). Recent studies have …