Background Transplantation of beta cells by pancreas or islet transplantation is the
treatment of choice for a selected group of patients suffering from type 1 diabetes mellitus …

Due to an increasing scarcity of pancreases with optimal donor characteristics, islet isolation
centers utilize pancreases from extended criteria donors, such as from donation after …

Introduction: Pancreas transplantation is currently one of the best treatments proposed in
highly selected patients with unstable and brittle type 1 diabetes. The objective of pancreas …

The standard technique for pancreas preservation for transplantation is static cold storage
(SCS). In this experimental study, we compare SCS to hypothermic machine perfusion …

Background Hypothermic machine perfusion (HMP) is increasingly being used for extended
criteria kidney grafts. Pancreatic HMP is challenging because physiologically the pancreas …

The demand for high-quality islets for transplantation in type I diabetics will increase as the
current clinical trials transition into standard of care. The mode of preservation of donor …

Pancreas or pancreatic islet transplantation is an important treatment option for insulin-
dependent diabetes and its complications. However, as the pancreas is particularly …

Maintaining organ viability between donation and transplantation is of critical importance for
optimal graft function and survival. To date in pancreas transplantation, static cold storage …

Abstract Purpose of Review Pancreas transplantation enables complete patient
independence from exogenous insulin administration and increases both patient survival …

Pancreas procurement for islet isolation and transplantation is limited by concerns for the
detrimental effects of postmortem ischemia. Hypothermic machine perfusion (HMP) …