Pancreatic cholesterol esterase (CEase) is a serine hydrolase involved in the hydrolysis of
variety of lipids and transport of free cholesterol. In this study, pharmacophore hypotheses …

Recently, the inhibitory impact of enzymes acetylcholinesterase (AChE) and
butyrylcholinesterase (BChE) have emerged as a hopeful approach for pharmacological …

The cholinergic hypothesis is one of the basic approaches for designing and discovering
novel anti-Alzheimer drugs. Application of the pharmacophore of well-known drugs like …

Tacrine was the first drug to be approved for Alzheimer's disease (AD) treatment, acting as a
cholinesterase inhibitor. The neuropathological hallmarks of AD are amyloid-rich senile …

In the present investigation, a series of dimethoxy or methylenedioxy substituted‐
cinnamamide derivatives containing tertiary amine moiety (N. N‐Dimethyl, N, N‐diethyl …

Flavonoids are one of the largest classes of plant secondary metabolites and are known to
possess a number of significant biological activities for human health. In this study, we …

We present a new class of inhibitors of pancreatic cholesterol esterase (CEase) based on
'priviledged'5-benzylidenerhodanine and 5-benzylidene-2, 4-thiazolidinedione structural …

This article aims to provide an updated description and comparison of the data currently
available in the literature (from the last 15 years) on the studied natural inhibitors of …

New coumaryl-thiazole derivatives with the acetamide moiety as a linker between the alkyl
chains and/or the heterocycle nucleus were synthesized and in vitro tested as …

The study was conducted to explore the anticholinesterase inhibition property of eugenol
derived molecules. Ten eugenol derivatives were synthesized and evaluated for the …