Immunological effects of iron oxide nanoparticles and iron-based complex drug formulations: Therapeutic benefits, toxicity, mechanistic insights, and translational …

A Shah, MA Dobrovolskaia - Nanomedicine: Nanotechnology, Biology and …, 2018 - Elsevier
Nanotechnology offers several advantages for drug delivery. However, there is the need for
addressing potential safety concerns regarding the adverse health effects of these unique …

A single exposure to iron oxide nanoparticles attenuates antigen-specific antibody production and T-cell reactivity in ovalbumin-sensitized BALB/c mice

CC Shen, CC Wang, MH Liao… - International journal of …, 2011 - Taylor & Francis
Background Superparamagnetic iron oxide nanoparticles have been used in clinical
applications as a diagnostic contrasting agent. Previous studies showed that iron oxide …

A role of cellular glutathione in the differential effects of iron oxide nanoparticles on antigen-specific T cell cytokine expression

CC Shen, HJ Liang, CC Wang, MH Liao… - International journal of …, 2011 - Taylor & Francis
Background Accumulating evidence indicates that iron oxide nanoparticles modulate
immune responses, and induce oxidative stress in macrophages. It was recently reported …

[HTML][HTML] The use of iron oxide nanoparticles to reprogram macrophage responses and the immunological tumor microenvironment

V Mulens-Arias, JM Rojas, DF Barber - Frontiers in immunology, 2021 - frontiersin.org
The synthesis and functionalization of iron oxide nanoparticles (IONPs) is versatile, which
has enhanced the interest in studying them as theranostic agents over recent years. As …

Current understanding of interactions between nanoparticles and the immune system

MA Dobrovolskaia, M Shurin, AA Shvedova - Toxicology and applied …, 2016 - Elsevier
The delivery of drugs, antigens, and imaging agents benefits from using nanotechnology-
based carriers. The successful translation of nanoformulations to the clinic involves thorough …

In vitro hematological and in vivo immunotoxicity assessment of dextran stabilized iron oxide nanoparticles

SL Easo, PV Mohanan - Colloids and Surfaces B: Biointerfaces, 2015 - Elsevier
Iron oxide nanoparticles have attracted enormous interest as potential therapeutic agents.
The purpose of this study was to examine the in vitro hematological toxicity and in vivo …

Iron oxide nanoparticles modulate lipopolysaccharide-induced inflammatory responses in primary human monocytes

S Grosse, J Stenvik, AM Nilsen - International journal of …, 2016 - Taylor & Francis
Co-stimulation of the immune system to more than one agent concomitantly is very common
in real life, and considering the increasing use of engineered nanoparticles and …

Toxicology of engineered nanomaterials: focus on biocompatibility, biodistribution and biodegradation

A Kunzmann, B Andersson, T Thurnherr, H Krug… - … et Biophysica Acta (BBA …, 2011 - Elsevier
BACKGROUND: It is widely believed that engineered nanomaterials will be increasingly
used in biomedical applications. However, before these novel materials can be safely …

Interactions of nanomaterials with the immune system

S Hussain, JAJ Vanoirbeek… - Wiley Interdisciplinary …, 2012 - Wiley Online Library
Abstract Evaluation of the immunomodulatory potentials of nanomaterials is essential for
developing safe and consumer‐friendly nanotechnology. Various nanomaterials interact …

Immunosuppressive and anti‐inflammatory properties of engineered nanomaterials

AN Ilinskaya, MA Dobrovolskaia - British journal of …, 2014 - Wiley Online Library
Nanoparticle interactions with various components of the immune system are determined by
their physicochemical properties such as size, charge, hydrophobicity and shape …