Background The HIV-1 proviral genome harbors multiple CpG islands (CpGIs), both in the
promoter and intragenic regions. DNA methylation in the promoter region has been shown …

Background Human immunodeficiency virus type 1 (HIV-1) latency represents the major
barrier to virus eradication in infected individuals because cells harboring latent HIV-1 …

ABSTRACT DNA methylation is an epigenetic mechanism most commonly associated with
transcriptional repression. While it is clear that DNA methylation can silence HIV proviral …

With approximately 38 million people living with HIV/AIDS globally, and a further 1.5 million
new global infections per year, it is imperative that we advance our understanding of all …

Efforts to cure HIV-1 infections aim at eliminating proviral DNA. Integrated DNA from various
viruses often becomes methylated de novo and transcriptionally inactivated. We therefore …

HIV-1 latency is a barrier to overcome in the effort to fully eradicate the virus from infected
individuals using highly active anti-retroviral therapy (HAART). Therefore, the study of the …

The latent HIV-1 reservoir is comprised of stably integrated and intact proviruses with limited
to no viral transcription. It has been proposed that latent infection may be maintained by …

Epigenetic control of human immunodeficiency virus-1 (HIV-1) genes is critical for viral
integration and latency. However, epigenetic changes in the HIV-1-infected host genome …

DNA methylation is one of the epigenetic modifications that configures gene transcription
programs. This study describes the DNA methylation profile of HIV-infected individuals with …

Background Human genetic variation—mostly in the human leukocyte antigen (HLA) and C–
C chemokine receptor type 5 (CCR5) regions—explains 25% of the variability in progression …