Underestimated effect of intragenic HIV-1 DNA methylation on viral transcription in infected individuals
Background The HIV-1 proviral genome harbors multiple CpG islands (CpGIs), both in the
promoter and intragenic regions. DNA methylation in the promoter region has been shown …
promoter and intragenic regions. DNA methylation in the promoter region has been shown …
Development of 5 'LTR DNA methylation of latent HIV-1 provirus in cell line models and in long-term-infected individuals
K Trejbalová, D Kovářová, J Blažková, L Machala… - Clinical …, 2016 - Springer
Background Human immunodeficiency virus type 1 (HIV-1) latency represents the major
barrier to virus eradication in infected individuals because cells harboring latent HIV-1 …
barrier to virus eradication in infected individuals because cells harboring latent HIV-1 …
Challenges in quantifying cytosine methylation in the HIV provirus
ABSTRACT DNA methylation is an epigenetic mechanism most commonly associated with
transcriptional repression. While it is clear that DNA methylation can silence HIV proviral …
transcriptional repression. While it is clear that DNA methylation can silence HIV proviral …
Deciphering DNA methylation in HIV infection
T Arumugam, U Ramphal, T Adimulam… - Frontiers in …, 2021 - frontiersin.org
With approximately 38 million people living with HIV/AIDS globally, and a further 1.5 million
new global infections per year, it is imperative that we advance our understanding of all …
new global infections per year, it is imperative that we advance our understanding of all …
[HTML][HTML] Epigenetic analysis of HIV-1 proviral genomes from infected individuals: predominance of unmethylated CpG's
S Weber, B Weiser, KS Kemal, H Burger, CM Ramirez… - Virology, 2014 - Elsevier
Efforts to cure HIV-1 infections aim at eliminating proviral DNA. Integrated DNA from various
viruses often becomes methylated de novo and transcriptionally inactivated. We therefore …
viruses often becomes methylated de novo and transcriptionally inactivated. We therefore …
In vivo, in vitro, and in silico analysis of methylation of the HIV-1 provirus
L Chávez, S Kauder, E Verdin - Methods, 2011 - Elsevier
HIV-1 latency is a barrier to overcome in the effort to fully eradicate the virus from infected
individuals using highly active anti-retroviral therapy (HAART). Therefore, the study of the …
individuals using highly active anti-retroviral therapy (HAART). Therefore, the study of the …
Cpg methylation profiles of HIV-1 proviral dna in individuals on art
VF Boltz, C Ceriani, JW Rausch, W Shao, MJ Bale… - Viruses, 2021 - mdpi.com
The latent HIV-1 reservoir is comprised of stably integrated and intact proviruses with limited
to no viral transcription. It has been proposed that latent infection may be maintained by …
to no viral transcription. It has been proposed that latent infection may be maintained by …
Epigenome-wide differential DNA methylation between HIV-infected and uninfected individuals
Epigenetic control of human immunodeficiency virus-1 (HIV-1) genes is critical for viral
integration and latency. However, epigenetic changes in the HIV-1-infected host genome …
integration and latency. However, epigenetic changes in the HIV-1-infected host genome …
Latency-associated DNA methylation patterns among HIV-1 infected individuals with distinct disease progression courses or antiretroviral virologic response
DNA methylation is one of the epigenetic modifications that configures gene transcription
programs. This study describes the DNA methylation profile of HIV-infected individuals with …
programs. This study describes the DNA methylation profile of HIV-infected individuals with …
The Genome-wide Methylation Profile of CD4+ T Cells From Individuals With Human Immunodeficiency Virus (HIV) Identifies Distinct Patterns Associated With …
S Moron-Lopez, V Urrea, J Dalmau… - Clinical Infectious …, 2021 - academic.oup.com
Background Human genetic variation—mostly in the human leukocyte antigen (HLA) and C–
C chemokine receptor type 5 (CCR5) regions—explains 25% of the variability in progression …
C chemokine receptor type 5 (CCR5) regions—explains 25% of the variability in progression …
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