Non‐alcoholic fatty liver disease: the bile acid‐activated farnesoid x receptor as an emerging treatment target

M Fuchs - Journal of lipids, 2012 - Wiley Online Library
Non‐alcoholic fatty liver disease (NAFLD) is currently evolving as the most common liver
disease worldwide. It may progress to liver cirrhosis and liver cancer and is poised to …

[HTML][HTML] Bile acid nuclear receptor farnesoid X receptor: therapeutic target for nonalcoholic fatty liver disease

SG Kim, BK Kim, K Kim, S Fang - Endocrinology and …, 2016 - synapse.koreamed.org
Nonalcoholic fatty liver disease (NAFLD) is one of the causes of fatty liver, occurring when
fat is accumulated in the liver without alcohol consumption. NAFLD is the most common liver …

[HTML][HTML] Role of farnesoid X receptor in hepatic steatosis in nonalcoholic fatty liver disease

Y Xi, H Li - Biomedicine & Pharmacotherapy, 2020 - Elsevier
With the increased incidence of obesity, nonalcoholic fatty liver disease (NAFLD) has
become a major global health concern. The pathogenesis of NAFLD has not yet been fully …

The farnesoid X receptor (FXR) as a new target in non-alcoholic steatohepatitis

B Cariou - Diabetes & metabolism, 2008 - Elsevier
The farnesoid X receptor (FXR) is a member of the nuclear receptor superfamily that is
mainly expressed in liver, intestine, kidney and adipose tissue. On activation by bile acids …

Farnesoid X receptor targeting to treat nonalcoholic steatohepatitis

L Adorini, M Pruzanski, D Shapiro - Drug discovery today, 2012 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) is a highly prevalent chronic liver condition
evolving in a proportion of patients into nonalcoholic steatohepatitis (NASH), an aggressive …

FXR agonists as therapeutic agents for non-alcoholic fatty liver disease

RM Carr, AE Reid - Current atherosclerosis reports, 2015 - Springer
Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic
syndrome and a risk factor for both cardiovascular and hepatic related morbidity and …

[HTML][HTML] Fatty liver diseases, bile acids, and FXR

Y Zhu, H Liu, M Zhang, GL Guo - Acta Pharmaceutica Sinica B, 2016 - Elsevier
The prevalence of nonalcoholic fatty liver disease (NAFLD) worldwide has increased at an
alarming rate, which will likely result in enormous medical and economic burden. NAFLD …

Pharmacologic modulation of bile acid-FXR-FGF15/FGF19 pathway for the treatment of nonalcoholic steatohepatitis

JD Schumacher, GL Guo - Bile Acids and Their Receptors, 2019 - Springer
Nonalcoholic steatohepatitis (NASH) is within the spectrum of nonalcoholic fatty liver
disease (NAFLD) and can progress to fibrosis, cirrhosis, and even hepatocellular carcinoma …

[HTML][HTML] Recent insights into farnesoid X receptor in non-alcoholic fatty liver disease

JY Xu, ZP Li, L Zhang, G Ji - World Journal of Gastroenterology …, 2014 - ncbi.nlm.nih.gov
Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic
syndrome and is one of the most prevalent liver disorders worldwide. NAFLD can gradually …

[HTML][HTML] Farnesoid X receptor: a master regulator of hepatic triglyceride and glucose homeostasis

Y Jiao, Y Lu, X Li - Acta Pharmacologica Sinica, 2015 - nature.com
Non-alcoholic fatty liver disease (NAFLD) is characterized by the aberrant accumulation of
triglycerides in hepatocytes in the absence of significant alcohol consumption, viral infection …