Low level natural antibodies against phosphorylcholine: a novel risk marker and potential mechanism in atherosclerosis and cardiovascular disease

J Frostegård - Clinical immunology, 2010 - Elsevier
Atherosclerosis is an inflammatory condition characterised by an abundance of activated
immunocompetent cells in plaques which cause cardiovascular disease (CVD) when they …

Natural antibodies against phosphorylcholine in cardiovascular disease

U De Faire, J Frostegård - Annals of the New York Academy of …, 2009 - Wiley Online Library
Atherosclerosis is a chronic inflammatory disease characterized by the presence of activated
immune‐competent cells in the lesions, producing mainly proinflammatory cytokines …

Antibodies against phosphorylcholine and protection against atherosclerosis, cardiovascular disease and chronic inflammation

J Frostegård - Expert Review of Clinical Immunology, 2022 - Taylor & Francis
Introduction Chronic inflammatory diseases include cardiovascular disease (CVD),
atherosclerosis, rheumatic and autoimmune diseases, and others, constituting a large part of …

Low levels of IgM antibodies to phosphorylcholine predict cardiovascular disease in 60-year old men: effects on uptake of oxidized LDL in macrophages as a potential …

U de Faire, J Su, X Hua, A Frostegård, M Halldin… - Journal of …, 2010 - Elsevier
OBJECTIVE: We here determine the role of IgM antibodies against phosphorylcholine (anti-
PC) in prediction of cardiovascular disease (CVD) and on macrophage uptake of Oxidized …

Low levels of IgM antibodies against phosphorylcholine—a potential risk marker for ischemic stroke in men

BG Sjöberg, J Su, I Dahlbom, H Grönlund, M Wikström… - Atherosclerosis, 2009 - Elsevier
BACKGROUND: Natural antibodies specific for phosphorylcholine (anti-PC) have been
implicated as protective factors in atherosclerosis. We herein determined the relationship …

Low levels of antibodies against phosphorylcholine predict development of stroke in a population-based study from northern Sweden

R Fiskesund, B Stegmayr, G Hallmans, M Vikström… - Stroke, 2010 - Am Heart Assoc
Background and Purpose—Natural immunoglobulin M antibodies specific for
phosphorylcholine (anti-PC) have been implicated in atherosclerosis. We have shown …

Natural antibodies against phosphorylcholine as potential protective factors in SLE

J Su, X Hua, H Concha, E Svenungsson… - …, 2008 - academic.oup.com
Objective. We have recently reported that natural antibodies against phosphorylcholine (anti-
PC) have atheroprotective properties. Here we compare anti-PC with other autoantibodies in …

Phosphorylcholine-targeting immunization reduces atherosclerosis

G Caligiuri, J Khallou-Laschet, M Vandaele… - Journal of the American …, 2007 - jacc.org
Objectives: The present study evaluated the effect of phosphorylcholine (PC) immunization
on the extent of experimental atherosclerosis. Background: Immunization against oxidized …

Low levels of IgM antibodies against phosphorylcholine predict development of acute myocardial infarction in a population-based cohort from northern Sweden

H Grönlund, G Hallmans, JH Jansson… - European Journal of …, 2009 - academic.oup.com
Objective Phosphorylcholine (PC) is one important epitope on oxidized low-density
lipoprotein that may play an important role by contributing to the atherogenicity of oxidized …

[HTML][HTML] IgM phosphorylcholine antibodies inhibit cell death and constitute a strong protection marker for atherosclerosis development, particularly in combination with …

R Fiskesund, J Su, I Bulatovic, M Vikström… - Results in …, 2012 - Elsevier
Background We have reported that anti-phosphorylcholine (anti-PC) IgM is a protection
marker for human cardiovascular disease (CVD) and atherosclerosis. We here investigate …