Alterations in sphingolipid metabolism are described to contribute to various neurological
disorders. We here determined the expression of enzymes involved in the sphingomyelin …

Multiple sclerosis (MS) is a chronic autoimmune demyelinating disease of the CNS.
Oligodendrocytes, the myelin-forming cells of the central nervous system (CNS), are target …

The imbalance in sphingolipid signaling may be critically linked to the upstream events in
the neurodegenerative cascade of Alzheimer's disease (AD). We analyzed the influence of …

Over the past decade, it was found that relatively simple sphingolipids, such as ceramide,
sphingosine, sphingosine-1-phosphate, and glucosylceramide play important roles in …

Lipid metabolism is abnormal in Alzheimer's disease (AD) brain leading to ceramide and
sphingosine accumulation and reduced levels of brain sphingosine-1-phosphate (S1P). We …

Spingolipids (SLs) are an important component of central nervous system (CNS) myelin
sheaths and affect the viability of brain cells (oligodendrocytes, neurons and astrocytes) that …

Multiple Sclerosis (MS) is the most common cause for permanent disability in young adults.
Current pathophysiological understanding has identified an autoaggressive immune …

Abstract Multiple Sclerosis (MuS) is a complex multifactorial neuropathology, resulting in
heterogeneous clinical presentation. A very active MuS research field concerns the …

Oligodendroglial injury is a pathological hallmark of many human white matter diseases,
including multiple sclerosis (MS) and periventricular leukomalacia (PVL). Critical regulatory …

Multiple sclerosis (MS) is a demyelinating disorder characterized by massive
neurodegeneration and profound axonal loss. Since myelin is enriched with sphingolipids …