Fingolimod attenuates ceramide-induced blood–brain barrier dysfunction in multiple sclerosis by targeting reactive astrocytes
R van Doorn, PG Nijland, N Dekker, ME Witte… - Acta …, 2012 - Springer
Alterations in sphingolipid metabolism are described to contribute to various neurological
disorders. We here determined the expression of enzymes involved in the sphingomyelin …
disorders. We here determined the expression of enzymes involved in the sphingomyelin …
Sphingolipids in multiple sclerosis
A Jana, K Pahan - Neuromolecular medicine, 2010 - Springer
Multiple sclerosis (MS) is a chronic autoimmune demyelinating disease of the CNS.
Oligodendrocytes, the myelin-forming cells of the central nervous system (CNS), are target …
Oligodendrocytes, the myelin-forming cells of the central nervous system (CNS), are target …
Fingolimod affects transcription of genes encoding enzymes of ceramide metabolism in animal model of Alzheimer's disease
H Jęśko, PL Wencel, S Wójtowicz, J Strosznajder… - Molecular …, 2020 - Springer
The imbalance in sphingolipid signaling may be critically linked to the upstream events in
the neurodegenerative cascade of Alzheimer's disease (AD). We analyzed the influence of …
the neurodegenerative cascade of Alzheimer's disease (AD). We analyzed the influence of …
Exploring sphingolipid implications in neurodegeneration
AV Alessenko, E Albi - Frontiers in Neurology, 2020 - frontiersin.org
Over the past decade, it was found that relatively simple sphingolipids, such as ceramide,
sphingosine, sphingosine-1-phosphate, and glucosylceramide play important roles in …
sphingosine, sphingosine-1-phosphate, and glucosylceramide play important roles in …
Dual dose-dependent effects of fingolimod in a mouse model of Alzheimer's disease
I Carreras, N Aytan, JK Choi, CM Tognoni… - Scientific reports, 2019 - nature.com
Lipid metabolism is abnormal in Alzheimer's disease (AD) brain leading to ceramide and
sphingosine accumulation and reduced levels of brain sphingosine-1-phosphate (S1P). We …
sphingosine accumulation and reduced levels of brain sphingosine-1-phosphate (S1P). We …
Signaling and regulatory functions of bioactive sphingolipids as therapeutic targets in multiple sclerosis
M Podbielska, H Krotkiewski, EL Hogan - Neurochemical Research, 2012 - Springer
Spingolipids (SLs) are an important component of central nervous system (CNS) myelin
sheaths and affect the viability of brain cells (oligodendrocytes, neurons and astrocytes) that …
sheaths and affect the viability of brain cells (oligodendrocytes, neurons and astrocytes) that …
Sphingolipids: important players in multiple sclerosis
R Halmer, S Walter, K Faßbender - Cellular Physiology and …, 2014 - karger.com
Multiple Sclerosis (MS) is the most common cause for permanent disability in young adults.
Current pathophysiological understanding has identified an autoaggressive immune …
Current pathophysiological understanding has identified an autoaggressive immune …
Enhanced release of acid sphingomyelinase-enriched exosomes generates a lipidomics signature in CSF of Multiple Sclerosis patients
D Pieragostino, I Cicalini, P Lanuti, E Ercolino… - Scientific Reports, 2018 - nature.com
Abstract Multiple Sclerosis (MuS) is a complex multifactorial neuropathology, resulting in
heterogeneous clinical presentation. A very active MuS research field concerns the …
heterogeneous clinical presentation. A very active MuS research field concerns the …
Aberrant upregulation of astroglial ceramide potentiates oligodendrocyte injury
SJ Kim, AJ Steelman, Y Zhang, HC Kinney… - Brain …, 2012 - Wiley Online Library
Oligodendroglial injury is a pathological hallmark of many human white matter diseases,
including multiple sclerosis (MS) and periventricular leukomalacia (PVL). Critical regulatory …
including multiple sclerosis (MS) and periventricular leukomalacia (PVL). Critical regulatory …
Sphingosine toxicity in EAE and MS: evidence for ceramide generation via serine-palmitoyltransferase activation
LG Miller, JA Young, SK Ray, G Wang, S Purohit… - Neurochemical …, 2017 - Springer
Multiple sclerosis (MS) is a demyelinating disorder characterized by massive
neurodegeneration and profound axonal loss. Since myelin is enriched with sphingolipids …
neurodegeneration and profound axonal loss. Since myelin is enriched with sphingolipids …