Identification of Cyclic Sulfonamides with an N-Arylacetamide Group as α-Glucosidase and α-Amylase Inhibitors: Biological Evaluation and Molecular Modeling
Diabetes mellitus (DM), a complicated metabolic disorder, is due to insensitivity to insulin
function or reduction in insulin secretion, which results in postprandial hyperglycemia. α …
function or reduction in insulin secretion, which results in postprandial hyperglycemia. α …
Synthesis and α-Glucosidase Inhibition Activity of 2-[3-(Benzoyl/4-bromobenzoyl)-4-hydroxy-1,1-dioxido-2H-benzo[e][1,2]thiazin-2-yl]-N-arylacetamides: An In Silico …
Diabetes mellitus (DM) is a chronic disorder and has affected a large number of people
worldwide. Insufficient insulin production causes an increase in blood glucose level that …
worldwide. Insufficient insulin production causes an increase in blood glucose level that …
Molecular Modeling and Synthesis of Indoline-2, 3-dione-Based Benzene Sulfonamide Derivatives and Their Inhibitory Activity against α-Glucosidase and α-Amylase …
Diabetes is also known as a critical and noisy disease. Hyperglycemia, that is, increased
blood glucose level is a common effect of uncontrolled diabetes, and over a period of time …
blood glucose level is a common effect of uncontrolled diabetes, and over a period of time …
2, 4-Dichloro-5-[(N-aryl/alkyl) sulfamoyl] benzoic acid derivatives: in vitro antidiabetic activity, molecular modeling and in silico ADMET screening
Background: Postprandial hyperglycemia can be reduced by inhibiting major carbohydrate
hydrolyzing enzymes, such as α-glucosidase and α-amylase which is an effective approach …
hydrolyzing enzymes, such as α-glucosidase and α-amylase which is an effective approach …
Synthesis, crystal structures, spectroscopic characterization and in vitro evaluation of the 4-sulfono-3-methoxycinnamaldehydes as potential α-glucosidase and/or α …
TP Mokoena, MM Maluleka, RM Mampa… - Journal of Molecular …, 2023 - Elsevier
Abstract The 4-sulfono-3-methoxycinnamaldehyde derivatives 2a–e were synthesized by
sulfonation of 4-hydroxy-3-methoxycinnamaldehyde 1 with alkyl or phenyl sulfonyl chlorides …
sulfonation of 4-hydroxy-3-methoxycinnamaldehyde 1 with alkyl or phenyl sulfonyl chlorides …
Evaluation of novel 2-(quinoline-2-ylthio) acetamide derivatives linked to diphenyl-imidazole as α-glucosidase inhibitors: Insights from in silico, in vitro, and in vivo …
MK Ghomi, M Noori, M Mirahmad, A Iraji… - European Journal of …, 2024 - Elsevier
The inhibition of the α-glucosidase enzyme is crucial for targeting type 2 diabetes mellitus
(DM). This study introduces a series of synthetic analogs based on thiomethylacetamide …
(DM). This study introduces a series of synthetic analogs based on thiomethylacetamide …
Exploring of novel 4-hydroxy-2H-benzo [e][1, 2] thiazine-3-carbohydrazide 1, 1-dioxide derivative as a dual inhibitor of α-glucosidase and α-amylase: Molecular …
Diabetes mellitus (DM) is a metabolic disorder that leads to hyperglycemia due to improper
insulin secretion. The study aims to investigate the anti-diabetic potential of benzothiazine …
insulin secretion. The study aims to investigate the anti-diabetic potential of benzothiazine …
α-Glucosidase and α-amylase inhibition, molecular modeling and pharmacokinetic studies of new quinazolinone-1, 2, 3-triazole-acetamide derivatives
A Yavari, M Mohammadi-Khanaposhtani… - Medicinal Chemistry …, 2021 - Springer
In this study, a new series of quinazolinone-1, 2, 3-triazole-acetamide hybrids 8a–m, using
by molecular hybridization of the potent α-glucosidase inhibitor pharmacophores, was …
by molecular hybridization of the potent α-glucosidase inhibitor pharmacophores, was …
Synthesis of Novel 2,3-Dihydro-1,5-Benzothiazepines as α-Glucosidase Inhibitors: In Vitro, In Vivo, Kinetic, SAR, Molecular Docking, and QSAR Studies
R Mehmood, EU Mughal, EB Elkaeed, RJ Obaid… - ACS …, 2022 - ACS Publications
In the present study, a series of 2, 3-dihydro-1, 5-benzothiazepine derivatives 1B–14B has
been synthesized sand characterized by various spectroscopic techniques. The enzyme …
been synthesized sand characterized by various spectroscopic techniques. The enzyme …
Recent developments in the synthesis of N‐heterocyclic compounds as α‐amylase inhibitors via in‐vitro and in‐silico analysis: Future drugs for treating diabetes
In nature, N‐heterocyclic compounds and their derivatives are abundant. They serve as the
building blocks of many biological entities, such as enzymes, alkaloids, hormones …
building blocks of many biological entities, such as enzymes, alkaloids, hormones …