Longitudinal study of immunity to SARS‐CoV2 in ocrelizumab‐treated MS patients up to 2 years after COVID‐19 vaccination

I Kister, R Curtin, AL Piquet, T Borko… - Annals of Clinical …, 2024 - Wiley Online Library
Objectives (1) To plot the trajectory of humoral and cellular immune responses to the primary
(two‐dose) COVID‐19 mRNA series and the third/booster dose in B‐cell‐depleted multiple …

Severe acute respiratory syndrome coronavirus 2 third vaccine immune response in multiple sclerosis patients treated with ocrelizumab

L Brill, C Raposo, A Rechtman, O Zveik… - Annals of …, 2022 - Wiley Online Library
The introduction of a third‐dose vaccination along with new variants of concern raises
questions regarding serology and T‐cell responses in patients with multiple sclerosis …

Humoral and T-cell response to SARS-CoV-2 vaccination in patients with multiple sclerosis treated with ocrelizumab

L Brill, A Rechtman, O Zveik, N Haham… - JAMA …, 2021 - jamanetwork.com
Importance B-cell–depleting therapies may affect the development of a protective immune
response following vaccination. Understanding the ability to develop vaccine-specific …

Hybrid and vaccine‐induced immunity against SAR‐CoV‐2 in MS patients on different disease‐modifying therapies

I Kister, R Curtin, J Pei, K Perdomo… - Annals of Clinical …, 2022 - Wiley Online Library
Objective To compare “hybrid immunity”(prior COVID‐19 infection plus vaccination) and post‐
vaccination immunity to SARS CoV‐2 in MS patients on different disease‐modifying …

[HTML][HTML] Evidence of extensive cellular immune response after SARS-CoV-2 vaccination in ocrelizumab-treated patients with multiple sclerosis

M Pompsch, N Fisenkci, PA Horn, M Kraemer… - … Research and Practice, 2021 - Springer
Background Patients with multiple sclerosis receiving ocrelizumab-treatment are in
desperate need of a protection against SARS-CoV-2 infection. Methods In this study …

[HTML][HTML] Preliminary evidence of blunted humoral response to SARS-CoV-2 mRNA vaccine in multiple sclerosis patients treated with ocrelizumab

A Gallo, R Capuano, G Donnarumma, A Bisecco… - Neurological …, 2021 - Springer
Objectives Several concerns regard the immunogenicity of SARS-CoV-2 vaccines in people
with multiple sclerosis (pwMS), since the majority of them is treated with immunomodulating …

Low protection from breakthrough SARS-CoV-2 infection and mild disease course in ocrelizumab-treated patients with multiple sclerosis after three mRNA vaccine …

F Novak, HM Bajwa, JE Coia, AC Nilsson… - Journal of Neurology …, 2023 - jnnp.bmj.com
Background Our study investigated the rate of breakthrough SARS-CoV-2 infection and
clinical outcomes in a cohort of multiple sclerosis (MS) patients who were treated with the …

Cellular and humoral immunity to SARS‐CoV‐2 infection in multiple sclerosis patients on ocrelizumab and other disease‐modifying therapies: a multi‐ethnic …

I Kister, Y Patskovsky, R Curtin, J Pei… - Annals of …, 2022 - Wiley Online Library
Objective The objective of this study was to determine the impact of multiple sclerosis (MS)
disease‐modifying therapies (DMTs) on the development of cellular and humoral immunity …

Immune response to SARS-CoV-2 vaccination in relation to peripheral immune cell profiles among patients with multiple sclerosis receiving ocrelizumab

S Räuber, M Korsen, N Huntemann, L Rolfes… - Journal of Neurology …, 2022 - jnnp.bmj.com
Background Vaccination has proven to be effective in preventing SARS-CoV-2 transmission
and severe disease courses. However, immunocompromised patients have not been …

[HTML][HTML] Vaccination responses in B‐cell‐depleted multiple sclerosis patients: The role of drug pharmacokinetics

J Killestein, ZLE van Kempen - European journal of neurology, 2022 - ncbi.nlm.nih.gov
Early reports prior to availability of vaccinations show that treatment with anti-CD20
monoclonal antibodies (eg, rituximab, ocrelizumab) in multiple sclerosis (MS) patients is …