Nitric oxide has been proven to play an important role in nociception, accordingly, its
promoters, phosphodiesterase inhibitors have been investigated as pain response …

Various evidence has demonstrated a role of the nitric oxide (NO)/cGMP signaling pathway
in the processing of nociception. The exact role of phosphodiesterase-5 (PDE-5) via the …

Although several lines of evidence have shown a role of the nitric oxide/cyclic guanosine
monophosphate signaling pathway in the nociceptive mechanism, the exact role of the …

In this study, we aimed to investigate the peripheral antinociception effects of specific
phosphodiesterase 5 (PDE-5) inhibitor vardenafil on carrageenan-induced nociception in …

The association of elevated level of cyclic guanosine monophosphate (cGMP) with inhibition
of hyperalgesia and involvement of nitric oxide (NO)-cGMP pathway in the modulation of …

Acetylcholine and cholinomimetic agents with predominant muscarinic action are known to
increase the concentration of cGMP by activation of nitric oxide signaling pathway in the …

Peripheral activation of the NO-cGMP pathway has been implicated in various nociceptive
conditions. The antinociceptive effect of the PDE-5 inhibitor, sildenafil, alone or in …

The antinociceptive activity of an inhibitor of phosphodiesterase 5 alone or combined with
morphine was assessed in the formalin test. Local administration of 1-[4-ethoxy-3-(6, 7 …

The aim of this investigation was to assess the role that NO plays in the antinociceptive
activity of tramadol using a rat model of neuropathic pain. Thirty male Wistar rats weighing …

Experimental studies have indicated the importance of cAMP and cGMP in modulation of
peripheral sensory neurons leading to hyperalgesic response. The concentration of both …