Both opioid and NMDA receptors have been known to be involved in pain processing in the
central nervous system as well as in the periphery. The effect of drugs acting on opioid and …

Purpose The phosphodiesterase 5 inhibitor sildenafil has antinociceptive effects, mediated
by an increase in cGMP. This study examined the role of spinal adenosine and serotonin …

We have previously reported that serotonin concentration was reduced in the brain of mice
with neuropathic pain and that it may be related to reduction of morphine analgesic effects …

Objectives The main purpose of this study was to assess the role of l-arginine/SNAP/NO/
cGMP/KATP channel pathway in analgesic effects of α-terpineol in mice. Methods Male …

Statins, belonging to a well‐known drug class used for lowering cholesterol through
competitive inhibition of 3‐hydroxy‐3‐methylglutaryl coenzyme A (HMG‐CoA) reductase …

The antinociceptive effects of honokiol and magnolol, two major bioactive constituents of the
bark of Magnolia officinalis, were investigated on animal paw licking responses and thermal …

Background Neuropathic pain is clinically challenging because it is resistant to alleviation by
morphine. The nuclear factor κB (NF-κB) and mitogen-activated protein kinase …

The pyrazol compounds are known to possess antipyretic, analgesic and anti-inflammatory
activities. This study was conducted to investigate the peripheral antinociceptive effect of the …

By applying a 12 day regimen of the non‐calorific sweetener, aspartame, in combination
with representative compounds of the calcium channel blocker and nitric oxide synthase …

The effects of methyleugenol, an essential oil isolated from Asiasari radix, on antinociception
were examined using the formalin test in mice. Oral administration of 10 mg/kg …