Objective: To study a possible interaction between tramadol, an opioid analgesic and
amlodipine, a dihydropyridine calcium channel blocker with proposed antinociceptive …

Objective: Ellagic acid (EA), a major polyphenolic compound of pomegranate juice,
produces antinociceptive effects, which are mediated through opioidergic and nitric oxide …

The activities of 2-phthalimidethyl nitrate (PTD-NO) and 2-phthalimidethanol (PTD-OH) were
recently demonstrated in models of pain and inflammation. We expanded our investigation …

Recent studies suggested that statins have anti-inflammatory effects beyond their lipid-
lowering properties. Since inflammation in the central nervous system was highly related to …

The potentiation of the antinociceptive effect of morphine by dipyrone (metamizol) and the
possible participation of a peripheral mechanism on such synergism were studied with the …

Nitroparacetamol (NCX‐701) is a newly synthesized nitric oxide‐releasing derivative of
paracetamol. Following ip administration, nitroparacetamol inhibits carrageenan‐induced …

The present study was conducted to evaluate the local antinociceptive actions of fluoxetine,
a selective serotonin reuptake inhibitor, and the possible involvement of the l …

Serotonin (5-HT) is known to be an important mediator in pain modulation. Some centrally
acting agents, like selective serotonin reuptake inhibitors (SSRIs), modulate pain. Activation …

Although N-methyl-D-aspartate (NMDA) receptor antagonists clearly attenuate the
development of tolerance to the antinociceptive effects of opioids, it is not clear whether they …

Male Wistar rats were administered with naloxone (1mg/kg ip) or MR 2266 (5mg/kg ip)
15min before paracetamol (400mg/kg ip) treatment and the pain threshold was evaluated …