Nifedipine, a calcium channel blocker, can modulate the nociceptive threshold. However,
the underlying mechanism, especially the role of HPA axis, on this effect has still not been …

Abstract N‐palmitoyl‐ethanolamine (PEA) is an endogenous substance that was first
identified in lipid tissue extracts. It has been classified as a CB2 receptor agonist …

The mechanism of the antinociceptive action of the phosphodiesterase 5 inhibitor, sildenafil,
was assessed in the formalin test. Local peripheral ipsilateral, but not contralateral …

Tramadol is a centrally acting analgesic that acts via μ-opioid agonism and by blocking the
neuronal uptake of norepinephrine and serotonin. Clonidine potentiates the antinociceptive …

Objective: Even after 100 years of discovery, the exact mechanisms for the analgesic action
of paracetamol are under scanner. It was recently proposed that paracetamol may act …

The influence of cyclooxygenase (COX) and NO synthase inhibitors on antinociceptive
action of acetaminophen (ACETA) was studied in rats. ACETA increased the nociceptive …

Neuropathy is one of the most frequent and continuously growing complications of diabetes.
Due to the multitude of mechanisms involved in the pathogenesis of diabetic neuropathy …

Background Neuropathic pain, and subsequent hypernociception, can be induced in mice
by paclitaxel (PTX) administration and partial sciatic nerve ligation (PSNL). Its …

Objectives: The objective of this study was to examine the effects of rofecoxib, meloxicam,
both cyclooxygenase-2 (COX-2) inhibitors and aminoguanidine hydrochloride, an inducible …

Tolerance to the analgesic effect of morphine is a major clinical problem which can be
managed by co-administration of another drug. This study investigated the ability of …