[HTML][HTML] Anticancer potential of lichens' secondary metabolites

Z Solárová, A Liskova, M Samec, P Kubatka… - Biomolecules, 2020 - mdpi.com
Lichens produce different classes of phenolic compounds, including anthraquinones,
xanthones, dibenzofuranes, depsides and depsidones. Many of them have revealed …

Ursolic acid induces apoptosis through mitochondrial intrinsic pathway and caspase‐3 activation in M4Beu melanoma cells

PO Harmand, R Duval, C Delage… - International journal of …, 2005 - Wiley Online Library
Over the coming years, skin cancer could become a significant public health problem.
Previous results indicate that ursolic acid (UA), a pentacyclic triterpene acid, has pleiotropic …

Lichens: a promising source of antibiotic and anticancer drugs

G Shrestha, LL St. Clair - Phytochemistry reviews, 2013 - Springer
Lichens are symbiotic associations between fungi and a photosynthetic alga and/or
cyanobacteria. Lichenized fungi have been found to produce a wide array of secondary …

Promising anticancer activity of a lichen, Parmelia sulcata Taylor, against breast cancer cell lines and genotoxic effect on human lymphocytes

F Ari, E Ulukaya, S Oran, S Celikler, S Ozturk, MZ Ozel - Cytotechnology, 2015 - Springer
Plants are still to be explored for new anti-cancer compounds because overall success in
cancer treatment is still not satisfactory. As a new possible source for such compounds, the …

Potential anticancer activity of lichen secondary metabolite physodic acid

V Cardile, ACE Graziano, R Avola, M Piovano… - Chemico-biological …, 2017 - Elsevier
Secondary metabolites present in lichens, which comprise aliphatic, cycloaliphatic, aromatic
and terpenic compounds, are unique with respect to those of higher plants and show …

Ursolic acid induces apoptosis through mitochondrial intrinsic pathway and suppression of ERK1/2 MAPK in HeLa cells

Y Li, X Lu, H Qi, X Li, X Xiao, J Gao - Journal of pharmacological sciences, 2014 - Elsevier
Ursolic acid (UA), a natural pentacyclic triterpenoid compound, has been demonstrated to
induce apoptosis in various tumors. The aim of the present study was to elucidate the …

[HTML][HTML] Antiproliferative, Antibacterial and Antifungal Activity of the Lichen Xanthoria parietina and Its Secondary Metabolite Parietin

A Basile, D Rigano, S Loppi, A Di Santi… - International journal of …, 2015 - mdpi.com
Lichens are valuable natural resources used for centuries throughout the world as medicine,
food, fodder, perfume, spices and dyes, as well as for other miscellaneous purposes. This …

[PDF][PDF] Proapoptotic and antimigratory effects of Pseudevernia furfuracea and Platismatia glauca on colon cancer cell lines

DS Šeklić, AD Obradović, MS Stanković… - Food technology and …, 2018 - hrcak.srce.hr
The aim of this study is to investigate cytotoxic, proapoptotic, antimigratory and pro-
antioxidant effects of methanol, acetone and ethyl acetate extracts of lichens Pseudevernia …

Ursolic acid triggers apoptosis in human osteosarcoma cells via caspase activation and the ERK1/2 MAPK pathway

CC Wu, CH Cheng, YH Lee, IL Chang… - Journal of agricultural …, 2016 - ACS Publications
Ursolic acid (UA), a naturally occurring pentacyclic triterpene acid found in many medicinal
herbs and edible plants, has been shown to trigger apoptosis in several lines of tumor cells …

Solubilization of poorly soluble lichen metabolites for biological testing on cell lines

T Kristmundsdóttir, E Jónsdóttir… - European Journal of …, 2005 - Elsevier
The depside atranorin and depsidone fumarprotocetraric acid, isolated from the lichens
Stereocaulon alpinum and Cetraria islandica, respectively, were chosen as prototypes for …