Reversal of the immunosuppressive properties of mesenchymal stem cells by tumor necrosis factor α in collagen‐induced arthritis

F Djouad, V Fritz, F Apparailly… - Arthritis & …, 2005 - Wiley Online Library
Objective Adult mesenchymal stem cells (MSCs) represent promising tools for therapeutic
applications such as tissue engineering and cellular therapy. Recent data suggest that, due …

Cell therapy using allogeneic bone marrow mesenchymal stem cells prevents tissue damage in collagen‐induced arthritis

A Augello, R Tasso, SM Negrini… - Arthritis & …, 2007 - Wiley Online Library
Abstract Objective Mesenchymal stem cells (MSCs) are precursors of tissue of mesenchymal
origin, but they also have the capacity to regulate the immune response by suppressing T …

Immunosuppressive effects of mesenchymal stem cells in collagen-induced mouse arthritis

F Mao, WR Xu, H Qian, W Zhu, YM Yan, QX Shao… - Inflammation …, 2010 - Springer
Objective The objective of this study was to investigate the efficacy of mesenchymal stem
cell (MSC) in the treatment of arthritis. Methods Mesenchymal stem cells were injected …

Mesenchymal stem cells are conditionally therapeutic in preclinical models of rheumatoid arthritis

A Papadopoulou, M Yiangou, E Athanasiou… - Annals of the …, 2012 - ard.bmj.com
Objective The role of mesenchymal stem cells (MSC) in experimental arthritis is undoubtedly
conflicting. This study explored the effect of bone marrow-derived MSC in previously …

Allogeneic mesenchymal stem cell and mesenchymal stem cell-differentiated chondrocyte suppress the responses of type II collagen-reactive T cells in rheumatoid …

ZH Zheng, XY Li, J Ding, JF Jia, P Zhu - Rheumatology, 2008 - academic.oup.com
Objective. Rheumatoid arthritis (RA) is a T-cell-mediated systematic disease and is usually
accompanied by articular cartilage damage. In the present study, we explored the effects of …

[HTML][HTML] Mesenchymal stem cell-conditioned medium reduces disease severity and immune responses in inflammatory arthritis

AG Kay, G Long, G Tyler, A Stefan, SJ Broadfoot… - Scientific reports, 2017 - nature.com
We evaluated the therapeutic potential of mesenchymal stem cell-conditioned medium (CM-
MSC) as an alternative to cell therapy in an antigen-induced model of arthritis (AIA). Disease …

[HTML][HTML] Discrepancy between the in vitro and in vivoeffects of murine mesenchymal stem cells on T-cell proliferation and collagen-induced arthritis

E Schurgers, H Kelchtermans, T Mitera… - Arthritis research & …, 2010 - Springer
Introduction The goal of this study is to analyze the potential immunosuppressive properties
of mesenchymal stem cells (MSC) on T cell proliferation and in collagen-induced arthritis …

[HTML][HTML] Are mesenchymal stromal cells immune cells?

MJ Hoogduijn - Arthritis research & therapy, 2015 - Springer
Mesenchymal stromal cells (MSCs) are considered to be promising agents for the treatment
of immunological disease. Although originally identified as precursor cells for mesenchymal …

[HTML][HTML] Mesenchymal stem cells in arthritic diseases

FH Chen, RS Tuan - Arthritis research & therapy, 2008 - Springer
Mesenchymal stem cells (MSCs), the nonhematopoietic progenitor cells found in various
adult tissues, are characterized by their ease of isolation and their rapid growth in vitro while …

[PDF][PDF] Role of mesenchymal stem cells in reestablishing immunologic tolerance in autoimmune rheumatic diseases

GIA MacDonald, A Augello, C De Bari - Arthritis and rheumatism, 2011 - academia.edu
The process of immunologic tolerance is critical in preventing autoimmune disease and
maintaining immune system homeostasis. Increased understanding regarding cytokine …