Many human pathogens produce phenotypic variants as a means to circumvent the host
immune system and enhance survival and, as a potential consequence, exhibit increased …

Molecular mechanisms mediating group A Streptococcus (GAS)-host interactions remain
poorly understood but are crucial for diagnostic, therapeutic, and vaccine development. An …

In recent years we have studied the relationship between strain genotypes and patient
phenotypes in group A Streptococcus (GAS), a model human bacterial pathogen that causes …

The molecular basis for bacterial responses to host signals during natural infections is
poorly understood. The gram-positive bacterial pathogen group A Streptococcus (GAS) …

Streptococcus pyogenes, also known as group A Streptococcus (GAS), causes mild human
infections such as pharyngitis and impetigo and serious infections such as necrotizing …

Molecular pathogenomic analysis of the human bacterial pathogen group A Streptococcus
has been conducted for a decade. Much has been learned as a consequence of the …

The identification of the molecular events responsible for strain emergence, enhanced
virulence, and epidemicity has been a long-pursued goal in infectious diseases research. A …

The molecular mechanisms underlying pathogen emergence in humans is a critical but
poorly understood area of microbiologic investigation. Serotype V group B Streptococcus …

Molecular factors that contribute to the emergence of new virulent bacterial subclones and
epidemics are poorly understood. We hypothesized that analysis of a population-based …

Group A streptococci (GAS) are genetically diverse. Determination of strain features can
reveal associations with disease and resistance and assist in vaccine formulation. We …