Nucleosome organization has a key role in transcriptional regulation, yet the precise
mechanisms establishing nucleosome locations and their effect on transcription are unclear …

Cellular DNA is packaged into chromatin, which is composed of regularly-spaced
nucleosomes with occasional gaps corresponding to active regulatory elements, such as …

Precise positioning of nucleosomes around regulatory sites is achieved by the action of
chromatin remodelers, which use the energy of ATP to slide, evict or change the composition …

Precise nucleosome organization at eukaryotic promoters is thought to be generated by
multiple chromatin remodeler (CR) enzymes and to affect transcription initiation. Using an …

Chromatin remodelers regulate genes by organizing nucleosomes around promoters, but
their individual contributions are obfuscated by the complex in vivo milieu of factor …

The nucleosome, the structural unit of chromatin, is known to play a central role in regulating
gene transcription from promoters. The last seven years have spawned a vast amount of …

Nucleosomes impede access to DNA. Therefore, nucleosome positioning is fundamental to
genome regulation. Nevertheless, the molecular nucleosome positioning mechanisms are …

Accessible chromatin is important for RNA polymerase II recruitment and transcription
initiation at eukaryotic promoters. We investigated the mechanistic links between promoter …

The chromatin landscape and promoter architecture are dominated by the interplay of
nucleosome and transcription factor (TF) binding to crucial DNA sequence elements …

Most promoters in yeast contain a nucleosome-depleted region (NDR), but the mechanisms
by which NDRs are established and maintained in vivo are currently unclear. We have …