lncRNAs in stress response

S Valadkhan, A Valencia-Hipólito - Long non-coding RNAs in human …, 2015 - Springer
All living organisms sense and respond to harmful changes in their intracellular and
extracellular environment through complex signaling pathways that lead to changes in gene …

Long noncoding RNAs as versatile molecular regulators of cellular stress response and homeostasis

J Scholda, TTA Nguyen, F Kopp - Human Genetics, 2024 - Springer
Normal cell and body functions need to be maintained and protected against endogenous
and exogenous stress conditions. Different cellular stress response pathways have evolved …

Long non‐coding RNAs coordinate cellular responses to stress

SC Lakhotia - Wiley Interdisciplinary Reviews: RNA, 2012 - Wiley Online Library
Following the initial discovery of the heat shock RNA omega (hsrω) gene of Drosophila
melanogaster to be non‐coding (nc) and also inducible by cell stress, other stress‐inducible …

Stressing the Regulatory Role of Long Non-Coding RNA in the Cellular Stress Response during Cancer Progression and Therapy

YZ Wu, YH Su, CY Kuo - Biomedicines, 2022 - mdpi.com
Cellular stress response is an important adaptive mechanism for regulating cell fate decision
when cells confront with stress. During tumorigenesis, tumor progression and the course of …

[HTML][HTML] Control of nucleolar stress and translational reprogramming by lncRNAs

Y Verheyden, L Goedert, E Leucci - Cell Stress, 2019 - ncbi.nlm.nih.gov
Under adverse environmental conditions, cells activate stress re-sponses that favour
adaptation or, in case of irreversible damage, induce cell death. Multiple stress response …

Long non-coding RNAs: major regulators of cell stress in cancer

P Connerty, RB Lock, CE De Bock - Frontiers in oncology, 2020 - frontiersin.org
Cellular stress can occur in many forms; oxidative stress caused by reactive oxygen species
(ROS), metabolic stress from increased metabolic programs and genotoxic stress in the form …

Non-coding RNAs in homeostasis, disease and stress responses: an evolutionary perspective

PP Amaral, ME Dinger, JS Mattick - Briefings in functional …, 2013 - academic.oup.com
Cells and organisms are subject to challenges and perturbations in their environment and
physiology in all stages of life. The molecular response to such changes, including insulting …

[HTML][HTML] A pathophysiological view of the long non-coding RNA world

F Di Gesualdo, S Capaccioli, M Lulli - Oncotarget, 2014 - ncbi.nlm.nih.gov
Because cells are constantly exposed to micro-environmental changes, they require the
ability to adapt to maintain a dynamic equilibrium. Proteins are considered critical for the …

Long non-coding RNAs (lncRNAs) and their transcriptional control of inflammatory responses

NW Mathy, XM Chen - Journal of Biological Chemistry, 2017 - ASBMB
Long non-coding RNAs (lncRNAs) have emerged as potential key regulators of the
inflammatory response, particularly by modulating the transcriptional control of inflammatory …

Stressing out over long noncoding RNA

TE Audas, S Lee - Biochimica et Biophysica Acta (BBA)-Gene Regulatory …, 2016 - Elsevier
Genomic studies have revealed that humans possess far fewer protein-encoding genes than
originally predicted. These over-estimates were drawn from the inherent developmental and …