Furanaphthoquinones are well known in medicinal chemistry for exhibiting relevant
structural heterogeneity and bioactivities. In this work, it was synthesized a series of …

Herein, we report the synthesis of 12 new naphthoquinone derivatives, 6 substituted 1, 4-
naphthoquinones and 6 heterocycle-fused naphthoquinones, as well as evaluation of their …

Four new naphthofuranquinones, obtained from 2-hydroxy-3-allyl-naphthoquinone (1) and
nor-lapachol (2), have their structures established by physical and X-ray analysis and their …

Severe infections with potentially fatal outcomes are caused by parasites from the genera
Trypanosoma and Leishmania (class Kinetoplastea). The diseases affect people of remote …

The regioselective synthesis of functionalized naphthoquinones via the formation and
capture of naphthoquinonynes has been used to prepare trypanocidal compounds. The …

The synthesis of dihydronaphthofurandione and dihydrofuroquinolinedione derivatives 4–11
was performed through Diels–Alder reactions of dihydrobenzofurandione 1 with several …

Over the past decades, a number of 1, 4‐naphthoquinones have been isolated from natural
resources and several of naphthoquinone derivatives with diverse structural motif have been …

In the search for new therapeutic alternatives for Chagas disease, a series of six aryloxy-
naphthoquinone derivatives were synthesized and evaluated in vitro against Trypanosoma …

Chagas disease is caused by the parasite Trypanosoma cruzi and affects approximately
eight million individuals in the developing world; it is also classified as a neglected tropical …

The available treatment for the prevention and cure of Chagas disease, caused by the
protozoan Trypanosoma cruzi, is still unsatisfactory. Thus, there is an urgent need to …