Characterization of ghrelin-like immunoreactivity in human plasma

M Patterson, KG Murphy, CW le Roux… - The Journal of …, 2005 - academic.oup.com
Ghrelin is a gastric peptide hormone that has an important role in appetite control and GH
release. Circulating ghrelin levels are inversely correlated with body mass index and …

Separate measurement of plasma levels of acylated and desacyl ghrelin in healthy subjects using a new direct ELISA assay

T Akamizu, T Shinomiya, T Irako… - The Journal of …, 2005 - academic.oup.com
Two forms of ghrelin, acylated and desacyl, circulate in plasma. Although acylation is
thought to be essential for ghrelin biological activities, recent studies have suggested that …

Stomach is a major source of circulating ghrelin, and feeding state determines plasma ghrelin-like immunoreactivity levels in humans

H Ariyasu, K Takaya, T Tagami, Y Ogawa… - The Journal of …, 2001 - academic.oup.com
Ghrelin, an endogenous ligand for the GH secretagogue receptor, was isolated from rat
stomach and is involved in a novel system for regulating GH release. Although previous …

Plasma ghrelin levels in lean and obese humans and the effect of glucose on ghrelin secretion

T Shiiya, M Nakazato, M Mizuta, Y Date… - The Journal of …, 2002 - academic.oup.com
Ghrelin, a novel GH-releasing peptide isolated from human and rat stomach, stimulates food
intake and GH secretion. We determined plasma ghrelin concentrations in patients with …

Comparison of competitive radioimmunoassays and two-site sandwich assays for the measurement and interpretation of plasma ghrelin levels

C Prudom, J Liu, J Patrie, BD Gaylinn… - The Journal of …, 2010 - academic.oup.com
Context: Ghrelin, an endogenous ligand for the GH secretagogue receptor, is an orexigenic
peptide hormone produced primarily by the stomach. Recent studies suggest significant …

Novel ghrelin assays provide evidence for independent regulation of ghrelin acylation and secretion in healthy young men

J Liu, CE Prudom, R Nass, SS Pezzoli… - The Journal of …, 2008 - academic.oup.com
Context: Ghrelin, an acylated peptide hormone secreted from the gut, regulates appetite and
metabolism. Elucidating its pattern of secretion in the fed and fasted states is important in the …

Plasma levels of active form of ghrelin during oral glucose tolerance test in patients with anorexia nervosa

Y Nakai, H Hosoda, K Nin, C Ooya… - European journal of …, 2003 - academic.oup.com
Objective Ghrelin is an acylated peptide, whose octanoyl modification is essential for its
biological activities. Previous studies demonstrated that fasting plasma ghrelin levels were …

Plasma levels of intact and degraded ghrelin and their responses to glucose infusion in anorexia nervosa

M Hotta, R Ohwada, H Katakami… - The Journal of …, 2004 - academic.oup.com
Abstract Octanoylated ghrelin (1–28)(intact ghrelin) is rapidly and easily degraded to
desoctanoyl forms or smaller fragments (degraded ghrelin). Plasma levels of intact and …

Insulin regulates plasma ghrelin concentration

MF Saad, B Bernaba, CM Hwu… - The Journal of …, 2002 - academic.oup.com
Ghrelin is a novel gastric peptide which stimulates growth hormone and has orexigenic and
adipogenic properties. Plasma ghrelin is influenced by nutritional status and is thought to …

Spontaneous 24-h ghrelin secretion pattern in fasting subjects: maintenance of a meal-related pattern

G Natalucci, S Riedl, A Gleiss, T Zidek… - European Journal of …, 2005 - academic.oup.com
Objective Ghrelin stimulates GH release and causes weight gain through increased food
intake and reduced fat utilization. Ghrelin levels were shown to rise in the preprandial period …