Cell-mediated cytotoxicity plays an important role in the clearance of noncytopathic viruses
from infected tissues. Perforin-dependent cytotoxic mechanisms have been noted to play an …

After intravenous injection of replication‐deficient adenovirus, hepatocytes are transduced
and express high levels of adenovirus‐encoded genes. However, adenovirally encoded …

Immunity to allogeneic MHC Ags is weak in rodent livers, raising questions as to the
mechanisms that might control responses in this organ. Infection with an adenovirus vector …

Cytotoxic T lymphocytes (CTL) play a major role in the recovery from primary viral infections
and the accompanying tissue injuries. However, it is unclear to what extent the two main …

Intravenous injection of type 5 adenovirus, deleted in the E1 and E3 regions, is shown to
result in expression of viral antigens in the liver, initiating lymphocyte infiltration and liver …

The Fas ligand (FasL)/Fas and the perforin‐granzyme cytotoxic pathways presumably play a
central role in the development of hepatocellular injury in viral hepatitis. To recognize the …

In chronic hepatitis C, Fas expression is up-regulated in the hepatocytes, especially near
liver-infiltrating lymphocytes, and Fas ligand is expressed on the lymphocytes. The presence …

Deficiency or inhibition of tumor necrosis factor (TNF) significantly prolongs hepatic
expression of recombinant adenoviral vectors. To explore mechanisms responsible for this …

The pathogenesis of the neurotropic strain of mouse hepatitis virus in Fas-deficient mice
suggested that Fas-mediated cytotoxicity may be required during viral clearance after the …

The current study was designed to explore the relative contribution of Fas ligand (FasL),
perforin, IFN-gamma, and TNF-alpha-induced death pathways in the pathogenesis of CTL …