Malignant tumors are often associated with denervation, suggesting the functional
implication of axonal guidance molecules in tumor growth. Here, we assessed the role of …

Highlights•Semaphorins and Plexins are crucial proteins in patterning central nervous
system.•Local and cerebrospinal fluid-derived Semaphorins/Plexins influence …

Plexin transmembrane receptors and their semaphorin ligands, as well as their co-receptors
(Neuropilin, Integrin, VEGFR2, ErbB2, and Met kinase) are emerging as key regulatory …

The semaphorins are a family of proteins originally identified as regulators of axon growth
that recently have been implicated in blood vessel development. The plexins are high affinity …

Semaphorins are cell surface and secreted proteins that provide axonal guidance in
neuronal tissues and regulate cell motility in many cell types. They act by binding a family of …

Background Initially characterized as axon guidance factors, semaphorins also have been
implicated to have critical roles in multiple physiological and developmental functions …

Semaphorins are key players in the control of neural circuit development. Recent studies
have uncovered several exciting and novel aspects of neuronal semaphorin signalling in …

Semaphorins are secreted, transmembrane, and GPI-linked proteins, defined by cysteine-
rich semaphorin protein domains, that have important roles in a variety of tissues. Humans …

Semaphorins were originally identified as axon guidance factors involved in the
development of the neuronal system. However, accumulating evidence indicates that …

Previously, we demonstrated that loss of SEMA3F, a secreted semaphorin encoded in 3p21.
3, is associated with higher stages in lung cancer and primary tumor cells studied with anti …