The majority of people infected with hepatitis C virus (HCV) fail to generate or maintain a T-
cell response effective for viral clearance. Evidence from murine chronic viral infections …

Infection with hepatitis C virus (HCV) is associated with persistence in the majority of
individuals. We demonstrate here that the inhibitory molecule programmed death-1 (PD-1) is …

Hepatitis C virus (HCV)-specific CD8 cell exhaustion may represent a mechanism of HCV
persistence. The inhibitory receptor PD-1 has been reported to be up-regulated in …

We monitored expression of PD-1 (a mediator of T-cell exhaustion and viral persistence) on
hepatitis C virus (HCV)-specific CD8+ and CD4+ T cells from blood and liver during acute …

BACKGROUND & AIMS: The immunoinhibitory receptor programmed death 1 (PD-1) is up-
regulated on dysfunctional virus-specific CD8 T cells during chronic viral infections, and …

BACKGROUND/AIMS: HCV-specific T cells in acute hepatitis C with subsequent chronic
evolution are dysfunctional and most of them express PD-1. The aim of the study was to …

Hepatitis C virus (HCV) is an important human pathogen that represents a model for chronic
infection given that the majority of infected individuals fail to clear the infection despite …

Abstract Virus-specific CD4+ T-cell response at the site of inflammation is believed to play a
decisive role for the course of viral disease. In hepatitis C virus (HCV) infection, the majority …

Hepatitis C virus (HCV) persistence is facilitated by exhaustion of CD8+ T cells that express
the inhibitory receptor programmed cell death 1 (PD-1). Blockade of PD-1 signaling …

Reports have shown that a negative T cell costimulatory pathway mediated by PD-1
(programmed death-1) and PDL-1 (programmed death ligand-1) is associated with T cell …