Rationale and background Tobacco use through cigarette smoking is the leading
preventable cause of death in the developed world. Nicotine, a psychoactive component of …

Tobacco use through cigarette smoking is the leading preventable cause of death in the
developed world. Nicotine, a psychoactive component of tobacco, appears to play a major …

Health hazards associated with nicotine and tobacco use are well known. A contributing
factor, the dependence producing potential of this drug, has become widely accepted …

Nicotine dependence is a disease of constantly growing importance. This mini-review
describes the effects of nicotine in humans and focuses on the various laboratory animal …

There is mounting evidence that nonpharmacological factors critically modulate the effects of
several drugs of abuse both in humans and experimental animals. This paper reviews …

BACKGROUND: Tobacco addiction is a relapsing disorder that constitutes a substantial
worldwide health problem, with evidence suggesting that nicotine and nicotine-associated …

Introduction Smoking and vaping throughout adolescence and early adulthood lead to
nicotine dependence. Nicotine withdrawal is associated with somatic and affective …

Tobacco use is a form of drug dependence, pharmacologically mediated by the actions of
nicotine at central and peripheral receptors. Nonpharmacological factors are also important …

Of the many drugs used by society at large (illicitly or licitly), nicotine, in the form of tobacco,
is the drug consumed most often. In the USA, about 50-60 million individuals, which …

Background: Animal models are critical to improve our understanding of the neuronal
mechanisms underlying nicotine withdrawal. Nicotine dependence in rodents can be …