Hepatocellular carcinoma (HCC) poses a significant global health concern, with its
incidence steadily increasing. The development of HCC is a multifaceted, multi-step process …

Despite recent advances in the understanding of the biologic basis of hepatocellular
carcinoma (HCC) development, the clinical management of the disease remains a major …

Hepatocellular carcinoma (HCC) is a highly prevalent, treatment-resistant malignancy with a
multifaceted molecular pathogenesis. Current evidence indicates that during …

Despite advances in the treatment of cancers through surgical procedures and new
pharmaceuticals, the treatment of hepatocellular carcinoma (HCC) remains challenging as …

The epidermal growth factor receptor (EGFR) pathway and Hippo signaling play an
important role in the carcinogenesis of hepatocellular carcinoma (HCC). However, the …

With an annual incidence of over 660,000 deaths, hepatocellular carcinoma (HCC) is the
third leading cause of cancer death globally. This disease is often diagnosed at an …

Importance of the field: Hepatocellular cancer (HCC) is the fifth most common malignancy
worldwide and third leading cause of cancer death. HCC is highly resistant to conventional …

Despite the recent introduction of new effective systemic agents, the survival of patients with
hepatocellular carcinoma (HCC) at advanced stages remains dismal. This underscores the …

Hepatocellular carcinoma (HCC) is an aggressive tumor with a poor prognosis that highly
expresses phosphatidylinositol 3-kinase (PI3K) and mitogen-activated protein kinase (ERK) …

Cancer progression results from activation of various signaling networks. Among these,
PI3K/Akt signaling contributes to proliferation, invasion, and inhibition of apoptosis …