Summary Objective The oncogenic PI3K/Akt/mTOR pathway is frequently activated in
hepatocellular carcinoma (HCC). The aim of this study is to investigate the anti-HCC effect of …

Hepatocellular carcinoma (HCC) is among the most frequently occurring cancers and the
leading causes of cancer mortality worldwide. Identification of the signaling pathways …

Background: Aberrant Ras/Raf/MAPK and PI3K/AKT/mTOR signaling pathways are found in
hepatocellular carcinoma (HCC). This study reports how sorafenib (a multi-kinase inhibitor) …

Hepatocellular carcinoma (HCC) is the sixth most common primary cancer with an
unsatisfactory long-term survival. Gain of function mutations of PIK3CA occur in a subset of …

Simple Summary The mitogen-activated protein kinase/extracellular signal-regulated kinase
(MAPK/ERK) signaling pathway is frequently activated in liver cancer, which is one of the …

Hepatocellular cancer (HCC) is currently the third leading cause of cancer death worldwide.
The prognosis of patients diagnosed with late-stage disease is dismal due to high resistance …

The poor prognosis of hepatocellular carcinoma (HCC), one of the most devastating cancers
worldwide, is due to frequent recurrence and metastasis. Among the metastatic factors in the …

Growth factors are known to favor both proliferation and survival of hepatocytes. In this work,
we investigated the role of 2 main signaling pathways, phosphoinositide 3-kinase (PI3K) …

Liver cancer is the fourth most common cause of cancer‐related death worldwide, with
hepatocellular carcinoma (HCC) being the main primary malignancy affecting the liver …

Abstract According to the International Agency for Research on Cancer, approximately
670,000 new cases of hepatocellular carcinoma (HCC) developed in 2005, making it the fifth …