The effect of total-body ionizing radiation on the digestive tract is dose-dependent and time-
dependent. At low doses (1.5 Gy), one observes only a short prodromal syndrome consisting …

Background. Cancer therapies increasingly achieve cure, but result in chronic moderate or
severe gastrointestinal side effects in millions of patients worldwide. Paradoxically, modern …

This review summarizes the current state of knowledge regarding the role of endothelial
dysfunction in the pathogenesis of early and delayed intestinal radiation toxicity and …

Radiotherapy of pelvic malignancies causes chronic radiation damage to the gut in
approximately 5% of patients. The injury can lead to local ischemia and fibrosis with the …

Wilhelm Roentgen1 discovered ionizing radiation in 1895. Within weeks of his discovery,
scientists throughout Europe and the United States were experimenting with radiation for …

Mucosal injury induced by radiation or chemotherapy is a common, painful, function
disrupting toxicity that, currently, has limited treatment options. The evolving understanding …

Radiotherapy is used in the treatment of approximately 50% of all malignancies including
gastrointestinal cancers. Radiation can be given prior to surgery (neoadjuvant radiotherapy) …

PURPOSE: Irradiation inflicts acute injuries to the intestinal mucosa with rapid apoptosis
induction and subsequent reduction in epithelial surface area. It may therefore be assumed …

Purpose: Recent studies have proposed that mucositis development is the same throughout
the gastrointestinal tract (GIT), as it is formed from one structure embryologically. Radiation …

Intestinal fibrosis is a marked feature of late radiation enteropathy. This study assessed the
time dose fractionation relationships of radiation-induced fibrosis in order to elucidate …