Abstract In eukaryotic DNA, 50–90% of the dinucleotide sequence CG is methylated. Most
methylated sites are apparently placed at fixed locations in the genome and this methylation …

ARE changes in DNA methylation patterns a cause or an effect of eukaryotic gene
expression? There are already many examples of an inverse correlation between the level …

Publisher Summary The chapter discusses on the DNA methylation and its possible
biological roles. The pattern of DNA methylation is species-specific. In the DNA of some …

DNA-mediated gene transfer was used to investigate the mode of inheritance of 5-
methylcytosine in mouse L cells. Unmethylated phi X174 replicative form DNA remains …

Is DNA methylation a key element in the regulation of vertebrate gene expression, or does it
play a minor part? There is support for both views in the recent literature, for while it is now …

An improved method of purification of DNA methylase from Krebs II ascites cells is reported.
The enzyme sediments at 8.3 S on glycerol-gradients and a major band on SDS …

DNA methylase has been purified 405-fold from Krebs II ascites cells. The purified enzyme is
homogeneous on SDS-poly acrylamide gel electrophoresis (molecular weight about 80,000) …

DNA-methylation patterns are important for regulating genome functions, and are
determined by the enzymatic processes of methylation and demethylation. The …

The biological importance of DNA methylation for gene expression in eukaryotes is
becoming increasingly evident1, 2, and a direct role of methylation in gene expression has …

The methylation of vertebrate DNA at the 5-position of∼ 3–10% of its cytosine residues
occurs in a sequence-specific and tissue-specific manner1–3 and has been implicated in …