Stem cells offer great promise within the field of regenerative medicine but despite
encouraging results, the large scale use of stem cells for therapeutic applications still faces …

This work offers a guided walkthrough of one of the most promising research areas in
modern life sciences, enabling a deeper understanding of involved concepts and …

The goal of pathway analysis is to identify the pathways significantly impacted in a given
phenotype. Many current methods are based on algorithms that consider pathways as …

Stem cells have the capability to self-renew and maintain their undifferentiated state or to
differentiate into one or more specialised cell types. Stem cell expansion and manipulation …

Background: Recently, a conceptually new approach for analyzing gene networks, the
Functional Influence Network (FIN) was presented. The FIN approach uses the measured …

Mathematical models of biological processes become more and more important in biology.
The aim is a holistic understanding of how processes such as cellular communication, cell …

Stem cell regeneration is a vital biological process in self-renewing tissues, governing
development and tissue homeostasis. Gene regulatory network dynamics are pivotal in …

Models describing the process of stem-cell differentiation are plentiful, and may offer insights
into the underlying mechanisms and experimentally observed behaviour. Waddington's …

High‐quality quantitative data generated under standardized conditions is critical for
understanding dynamic cellular processes. We report strategies for error reduction, and …

Regulatory networks structure and signaling pathways dynamics are uncovered in time-and
resource consuming experimental work. However, it is increasingly supported by modeling …