The initial step in the process of atherosclerosis is supposed to be an increased penetration
of lipoprotein particles (especially LDL or Lp (a)) into the subendothelial space. It occurs …

The author discusses a new concept of atherogenesis which is based on older hypotheses
(lipid infiltration hypothesis), theory of impaired endothelial barrier, role of immunological …

Publisher Summary The development of atherosclerosis is induced by deposition of low
density lipoproteins (LDL) in the arterial walls and followed by migration of monocytes from …

The lipoproteids of low and very low density (LDL and VLDL), being the main carriers of
plasma cholesterol, in their interaction with the arterial wall constitute the material basis for …

Atherosclerosis and its complications constitute the most common causes of death in
Western societies and Japan. Although several theories or hypotheses about atherogenesis …

One of the first manifestations of atherosclerosis is accumulation of extra-and intracellular
cholesterol esters in the arterial intima. Formation of foam cells is considered as a trigger in …

The precise mechanisms of LDL oxidation in vivo are not well-known but the presence of
several enzymes and agents capable of modifying LDL particles was noted in arterial wall …

The study of the coronary arteries atherogenesis with the use of scanning and transmission
electron microscopy was performed on the material of emergency necropsies of 45 patients …

It appears that retention of lipoproteins rather than increased influx is the basis for
lipoprotein deposition in arterial tissue during atherogenesis. Binding of lipoproteins to …

Lipoprotein (LP) metabolism plays a pivotal role in atherogenesis. Breakdown of triglyceride
(TG) rich lipoproteins, both of exogenous--chylomicrones and endogenous--very low density …