Bioinformatics challenges in genome-wide association studies (GWAS)

R De, WS Bush, JH Moore - Clinical Bioinformatics, 2014 - Springer
Genome-wide association studies (GWAS) are a powerful tool for investigators to examine
the human genome to detect genetic risk factors, reveal the genetic architecture of diseases …

Bioinformatics challenges for genome-wide association studies

JH Moore, FW Asselbergs, SM Williams - Bioinformatics, 2010 - academic.oup.com
Motivation: The sequencing of the human genome has made it possible to identify an
informative set of> 1 million single nucleotide polymorphisms (SNPs) across the genome …

Genome-wide association studies

E Uffelmann, QQ Huang, NS Munung… - Nature Reviews …, 2021 - nature.com
Genome-wide association studies (GWAS) test hundreds of thousands of genetic variants
across many genomes to find those statistically associated with a specific trait or disease …

Benefits and limitations of genome-wide association studies

V Tam, N Patel, M Turcotte, Y Bossé, G Paré… - Nature Reviews …, 2019 - nature.com
Genome-wide association studies (GWAS) involve testing genetic variants across the
genomes of many individuals to identify genotype–phenotype associations. GWAS have …

Chapter 11: Genome-wide association studies

WS Bush, JH Moore - PLoS computational biology, 2012 - journals.plos.org
Genome-wide association studies (GWAS) have evolved over the last ten years into a
powerful tool for investigating the genetic architecture of human disease. In this work, we …

Prioritizing GWAS results: a review of statistical methods and recommendations for their application

RM Cantor, K Lange, JS Sinsheimer - The American Journal of Human …, 2010 - cell.com
Genome-wide association studies (GWAS) have rapidly become a standard method for
disease gene discovery. A substantial number of recent GWAS indicate that for most …

GWASdb: a database for human genetic variants identified by genome-wide association studies

MJ Li, P Wang, X Liu, EL Lim, Z Wang… - Nucleic acids …, 2012 - academic.oup.com
Recent advances in genome-wide association studies (GWAS) have enabled us to identify
thousands of genetic variants (GVs) that are associated with human diseases. As next …

Genome-wide association studies—data generation, storage, interpretation, and bioinformatics

G Pare - Journal of cardiovascular translational research, 2010 - Springer
Genome-wide association studies (GWAS) have had great success in identifying common
genetic determinants of disease. One of the challenges posed by GWAS is the analysis of …

Statistical methods for genome-wide association studies

MH Wang, HJ Cordell, K Van Steen - Seminars in cancer biology, 2019 - Elsevier
Genome-wide association studies (GWAS) detect common genetic variants associated with
complex disorders. With their comprehensive coverage of common single nucleotide …

15 years of genome-wide association studies and no signs of slowing down

RJF Loos - Nature Communications, 2020 - nature.com
Over the past 15 years, genome-wide association studies (GWASs) have generated a
wealth of new information. Larger samples sizes, refined phenotypes and higher-resolution …