Bioinformatics challenges in genome-wide association studies (GWAS)
Genome-wide association studies (GWAS) are a powerful tool for investigators to examine
the human genome to detect genetic risk factors, reveal the genetic architecture of diseases …
the human genome to detect genetic risk factors, reveal the genetic architecture of diseases …
Bioinformatics challenges for genome-wide association studies
Motivation: The sequencing of the human genome has made it possible to identify an
informative set of> 1 million single nucleotide polymorphisms (SNPs) across the genome …
informative set of> 1 million single nucleotide polymorphisms (SNPs) across the genome …
Genome-wide association studies
Genome-wide association studies (GWAS) test hundreds of thousands of genetic variants
across many genomes to find those statistically associated with a specific trait or disease …
across many genomes to find those statistically associated with a specific trait or disease …
Benefits and limitations of genome-wide association studies
Genome-wide association studies (GWAS) involve testing genetic variants across the
genomes of many individuals to identify genotype–phenotype associations. GWAS have …
genomes of many individuals to identify genotype–phenotype associations. GWAS have …
Chapter 11: Genome-wide association studies
Genome-wide association studies (GWAS) have evolved over the last ten years into a
powerful tool for investigating the genetic architecture of human disease. In this work, we …
powerful tool for investigating the genetic architecture of human disease. In this work, we …
Prioritizing GWAS results: a review of statistical methods and recommendations for their application
Genome-wide association studies (GWAS) have rapidly become a standard method for
disease gene discovery. A substantial number of recent GWAS indicate that for most …
disease gene discovery. A substantial number of recent GWAS indicate that for most …
GWASdb: a database for human genetic variants identified by genome-wide association studies
Recent advances in genome-wide association studies (GWAS) have enabled us to identify
thousands of genetic variants (GVs) that are associated with human diseases. As next …
thousands of genetic variants (GVs) that are associated with human diseases. As next …
Genome-wide association studies—data generation, storage, interpretation, and bioinformatics
G Pare - Journal of cardiovascular translational research, 2010 - Springer
Genome-wide association studies (GWAS) have had great success in identifying common
genetic determinants of disease. One of the challenges posed by GWAS is the analysis of …
genetic determinants of disease. One of the challenges posed by GWAS is the analysis of …
Statistical methods for genome-wide association studies
Genome-wide association studies (GWAS) detect common genetic variants associated with
complex disorders. With their comprehensive coverage of common single nucleotide …
complex disorders. With their comprehensive coverage of common single nucleotide …
15 years of genome-wide association studies and no signs of slowing down
RJF Loos - Nature Communications, 2020 - nature.com
Over the past 15 years, genome-wide association studies (GWASs) have generated a
wealth of new information. Larger samples sizes, refined phenotypes and higher-resolution …
wealth of new information. Larger samples sizes, refined phenotypes and higher-resolution …