Resveratrol Derivative, Trans‐3, 5, 4 ‐Trimethoxystilbene Sensitizes Osteosarcoma Cells to Apoptosis via ROS‐Induced Caspases Activation

Y Feng, J Clayton, W Yake, J Li, W Wang… - Oxidative Medicine …, 2021 - Wiley Online Library
Numerous studies have shown that resveratrol can induce apoptosis in cancer cells. Trans‐
3, 5, 4′‐trimethoxystilbene (TMS), a novel derivative of resveratrol, is a more potent …

Resveratrol sensitizes HepG2 cells to TRAIL-induced apoptosis

M Tameda, K Sugimoto, K Shiraki, Y Inagaki… - Anti-cancer …, 2014 - journals.lww.com
Resveratrol is a natural polyphenol found in a wide variety of plants, including grapes,
berries, and peanuts. Resveratrol can modulate a wide spectrum of molecular targets …

Molecular mechanisms of resveratrol (3, 4, 5-trihydroxy-trans-stilbene) and its interaction with TNF-related apoptosis inducing ligand (TRAIL) in androgen-insensitive …

S Shankar, I Siddiqui, RK Srivastava - Molecular and cellular biochemistry, 2007 - Springer
Although resveratrol, an active ingredient derived from grapes and red wine, possesses
chemopreventive properties against several cancers, the molecular mechanisms by which it …

Resveratrol-mediated sensitisation to TRAIL-induced apoptosis depends on death receptor and mitochondrial signalling

S Fulda, KM Debatin - European Journal of Cancer, 2005 - Elsevier
Natural food products such as resveratrol have gained considerable attention as cancer
chemopreventive agents. In the present study, we investigated the potential of resveratrol to …

Resveratrol enhances antitumor activity of TRAIL in prostate cancer xenografts through activation of FOXO transcription factor

S Ganapathy, Q Chen, KP Singh, S Shankar… - PloS one, 2010 - journals.plos.org
Background Resveratrol (3, 4′, 5 tri-hydroxystilbene), a naturally occurring polyphenol,
exhibits anti-inflammatory, antioxidant, cardioprotective and antitumor activities. We have …

Pterostilbene enhances TRAIL-induced apoptosis through the induction of death receptors and downregulation of cell survival proteins in TRAIL-resistance triple …

CM Hung, LC Liu, CT Ho, YC Lin… - Journal of agricultural …, 2017 - ACS Publications
Tumor necrosis factor-related apoptosis-induced ligand (TRAIL) is nontoxic to normal cells
and preferentially cytotoxic to cancer cells. Recent data suggest that malignant breast …

Targeting of cancer cell death mechanisms by resveratrol: a review

X Fu, M Li, C Tang, Z Huang, M Najafi - Apoptosis, 2021 - Springer
Cancer cell death is the utmost aim in cancer therapy. Anti-cancer agents can induce
apoptosis, mitotic catastrophe, senescence, or autophagy through the production of free …

Sensitization for tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by the chemopreventive agent resveratrol

S Fulda, KM Debatin - Cancer research, 2004 - AACR
Survivin is a member of the inhibitor of apoptosis proteins that is expressed at high levels in
most human cancers and may facilitate evasion from apoptosis and aberrant mitotic …

In vitro comparative studies of resveratrol and triacetylresveratrol on cell proliferation, apoptosis, and STAT3 and NFκB signaling in pancreatic cancer cells

JJ Duan, W Yue, JY E, J Malhotra, S Lu, J Gu, F Xu… - Scientific reports, 2016 - nature.com
Resveratrol (RES) has been studied extensively as an anticancer agent. However, the
anticancer effects of triacetylresveratrol (TRES, an acetylated analog of RES) which has …

[HTML][HTML] Sensitization of TRAIL-resistant LNCaP cells by resveratrol (3, 4', 5 tri-hydroxystilbene): molecular mechanisms and therapeutic potential

S Shankar, Q Chen, I Siddiqui, K Sarva… - Journal of Molecular …, 2007 - Springer
Background We have previously shown that prostate cancer LNCaP cells are resistant to
TRAIL, and downregulation of PI-3K/Akt pathway by molecular and pharmacological means …