The endothelial glycocalyx and neonatal sepsis
A Fatmi, W Saadi, J Beltrán-García… - International Journal of …, 2022 - mdpi.com
Sepsis carries a substantial risk of morbidity and mortality in newborns, especially preterm-
born neonates. Endothelial glycocalyx (eGC) is a carbohydrate-rich layer lining the vascular …
born neonates. Endothelial glycocalyx (eGC) is a carbohydrate-rich layer lining the vascular …
The endothelial glycocalyx: physiology and pathology in neonates, infants and children
A Puchwein-Schwepcke… - Frontiers in Cell and …, 2021 - frontiersin.org
The endothelial glycocalyx (EG) as part of the endothelial surface layer (ESL) is an important
regulator of vascular function and homeostasis, including permeability, vascular tone …
regulator of vascular function and homeostasis, including permeability, vascular tone …
The endothelial glycocalyx: new diagnostic and therapeutic approaches in sepsis
L Martin, P Koczera, E Zechendorf… - BioMed research …, 2016 - Wiley Online Library
Sepsis is defined as a life‐threatening organ dysfunction caused by a dysregulated host
response to infection. The endothelial glycocalyx is one of the earliest sites involved during …
response to infection. The endothelial glycocalyx is one of the earliest sites involved during …
[HTML][HTML] The endothelial glycocalyx in critical illness: A pediatric perspective
The vascular endothelium is the interface between circulating blood and end organs and
thus has a critical role in preserving organ function. The endothelium is lined by a glycan …
thus has a critical role in preserving organ function. The endothelium is lined by a glycan …
The endothelial glycocalyx as a double-edged sword in microvascular homeostasis and pathogenesis
N Villalba, S Baby, SY Yuan - Frontiers in Cell and Developmental …, 2021 - frontiersin.org
Expressed on the endothelial cell (EC) surface of blood vessels, the glycocalyx (GCX), a
mixture of carbohydrates attached to proteins, regulates the access of cells and molecules in …
mixture of carbohydrates attached to proteins, regulates the access of cells and molecules in …
The endothelial glycocalyx: a fundamental determinant of vascular permeability in sepsis
J Fernández-Sarmiento… - Pediatric Critical Care …, 2020 - journals.lww.com
Objectives: Sepsis is a significant cause of morbidity and mortality. Children with sepsis
often have alterations in microcirculation and vascular permeability. Our objective is current …
often have alterations in microcirculation and vascular permeability. Our objective is current …
[HTML][HTML] Protection and rebuilding of the endothelial glycocalyx in sepsis–Science or fiction?
The endothelial glycocalyx (eGC), a delicate carbohydrate-rich structure lining the luminal
surface of the vascular endothelium, is vital for maintenance of microvascular homeostasis …
surface of the vascular endothelium, is vital for maintenance of microvascular homeostasis …
Glycocalyx impairment in vascular disease: focus on inflammation
J Qu, Y Cheng, W Wu, L Yuan, X Liu - Frontiers in Cell and …, 2021 - frontiersin.org
The glycocalyx is a complex polysaccharide-protein layer lining the lumen of vascular
endothelial cells. Changes in the structure and function of the glycocalyx promote an …
endothelial cells. Changes in the structure and function of the glycocalyx promote an …
[HTML][HTML] Endothelial glycocalyx degradation during sepsis: Causes and consequences
RC Sullivan, MD Rockstrom, EP Schmidt… - Matrix Biology Plus, 2021 - Elsevier
The glycocalyx is a ubiquitous structure found on endothelial cells that extends into the
vascular lumen. It is enriched in proteoglycans, which are proteins attached to the …
vascular lumen. It is enriched in proteoglycans, which are proteins attached to the …
[HTML][HTML] Derangement of the endothelial glycocalyx in sepsis
The vascular endothelial surface is coated by the glycocalyx, a ubiquitous gel‐like layer
composed of a membrane‐binding domain that contains proteoglycans, glycosaminoglycan …
composed of a membrane‐binding domain that contains proteoglycans, glycosaminoglycan …
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