Congenital heart disease and genetic syndromes: new insights into molecular mechanisms

G Calcagni, M Unolt, MC Digilio, A Baban… - Expert review of …, 2017 - Taylor & Francis
Introduction: Advances in genetics allowed a better definition of the role of specific genetic
background in the etiology of syndromic congenital heart defects (CHDs). The identification …

Congenital heart diseases: genetics, non-inherited risk factors, and signaling pathways

E Suluba, L Shuwei, Q Xia, A Mwanga - Egyptian Journal of Medical …, 2020 - Springer
Abstract Background Congenital heart diseases (CHDs) are the most common congenital
anomalies with an estimated prevalence of 8 in 1000 live births. CHDs occur as a result of …

Congenital heart disease: the crossroads of genetics, epigenetics and environment

C Vecoli, S Pulignani, I Foffa… - Current …, 2014 - ingentaconnect.com
Congenital heart diseases (CHDs) are recognized as the most common type of birth
malformations. Although recent advances in pre-and neonatal diagnosis as well as in …

Genetics of congenital heart disease: the contribution of the noncoding regulatory genome

AV Postma, CR Bezzina, VM Christoffels - Journal of human genetics, 2016 - nature.com
Congenital heart disease (CHD) is the most common type of birth defect. The advent of
corrective cardiac surgery and the increase in knowledge concerning the longitudinal care …

Genetic contribution to congenital heart disease (CHD)

NA Shabana, SU Shahid, U Irfan - Pediatric cardiology, 2020 - Springer
Congenital heart defects (CHD) are the most common congenital problems in neonates. The
basis for CHD is multifactorial, involving genetic and environmental components. The …

An update on the molecular diagnosis of congenital heart disease: focus on loss-of-function mutations

YJ Li, YQ Yang - Expert Review of Molecular Diagnostics, 2017 - Taylor & Francis
Introduction: Congenital heart disease (CHD) is the most common birth defect in humans. In
spite of tremendous advance in medical care, CHD is still a major contributor to substantial …

[HTML][HTML] Genetics of congenital heart disease: a narrative review of recent advances and clinical implications

J Yasuhara, V Garg - Translational Pediatrics, 2021 - ncbi.nlm.nih.gov
Congenital heart disease (CHD) is the most common human birth defect and remains a
leading cause of mortality in childhood. Although advances in clinical management have …

Molecular mechanisms of congenital heart disease

H Jing-bin, L Ying-long, S Pei-wu, L Xiao-dong… - Cardiovascular …, 2010 - Elsevier
BACKGROUND: Congenital heart disease (CHD) is the most common type of birth defect.
Despite the many advances in our understanding of cardiac development and many genes …

Molecular genetics and complex inheritance of congenital heart disease

NS Diab, S Barish, W Dong, S Zhao, G Allington, X Yu… - Genes, 2021 - mdpi.com
Congenital heart disease (CHD) is the most common congenital malformation and the
leading cause of mortality therein. Genetic etiologies contribute to an estimated 90% of CHD …

[HTML][HTML] Genetic and epigenetic mechanisms in the development of congenital heart diseases

Y Wu, X Jin, Y Zhang, J Zheng… - World Journal of Pediatric …, 2021 - ncbi.nlm.nih.gov
Congenital heart disease (CHD) is the most common of congenital cardiovascular
malformations associated with birth defects, and it results in significant morbidity and …