Abstract TRPM2 is a Ca 2+-permeable non-selective cation channel that can be activated by
adenosine dinucleotides, hydrogen peroxide, or intracellular Ca 2+. The protein is …

Insulin secretion from pancreatic β-cells is the primary mechanism by which the body lowers
blood glucose concentrations. Glucose is the principal stimulator of insulin secretion, and …

TRPM4 is a Ca2+-activated non-selective cation (CAN) channel that functions in cell
depolarization, which is important for Ca2+ influx and insulin secretion in pancreatic β-cells …

OBJECTIVE TRPM2 is a Ca2+-permeable nonselective cation channel activated by
adenosine dinucleotides. We previously demonstrated that TRPM2 is activated by …

TRPM4 is a calcium-activated non-selective cation channel that is widely expressed and
proposed to be involved in cell depolarization. In excitable cells, TRPM4 may regulate …

Insulin secretion in β-pancreatic cells due to glucose stimulation requires the coordinated
alteration of cellular ion concentrations and a substantial membrane depolarization to …

In pancreatic β-cells of the line INS-1, glucose uptake and metabolism induce the openings
of Ca2+-permeable TRPM3 channels that contribute to the elevation of the intracellular …

Glucose homeostasis is critically dependent on insulin release from pancreatic β-cells,
which is strictly regulated by glucose-induced oscillations in membrane potential (Vm) and …

TRPM2 is a cation channel enabling influx of Na+ and Ca 2+, leading to depolarization and
increases in the cytosolic Ca 2+ concentration ([Ca 2+] i). It is widely expressed, eg in many …

The means by which glucose stimulates insulin secretion from pancreatic β-cells has been
stud-ied for decades. Yet we still do not fully understand the cellular machinery underlying …