Kit/SCF signaling and Mitf-dependent transcription are both essential for melanocyte
development and pigmentation. To identify Mitf-dependent Kit transcriptional targets in …

Melanoma is a therapy-resistant skin cancer due to numerous mechanisms supporting cell
survival. Although components of melanoma cytoprotective mechanisms are overexpressed …

Microphthalmia (Mi) is a bHLHZip transcription factor that is essential for melanocyte
development and postnatal function. It is thought to regulate both differentiated features of …

Microphthalmia-associated transcription factor (MITF) acts as a master regulator of
melanocyte development, function and survival by modulating various differentiation and …

During melanocyte development, the cytokine Steel factor activates its receptor c-Kit,
initiating a signal transduction cascade, which is vital for lineage determination via unknown …

Tumours comprise multiple phenotypically distinct subpopulations of cells, some of which
are proposed to possess stem cell‐like properties, being able to self‐renew, seed and …

Kit‐ligand (Kitl) also known as steel factor, stem cell factor and mast cell growth factor plays
a crucial role in the development and maintenance of the melanocyte lineage in adult skin …

MITF (microphthalmia-associated transcription factor) represents a melanocytic lineage-
specific transcription factor whose role is profoundly extended in malignant melanoma. Over …

MITF governs multiple steps in the development of melanocytes, including specification from
neural crest, growth, survival, and terminal differentiation. In addition, the level of MITF …

The Mitf gene has a key role in melanocytes and melanoma by regulating cell cycle
progression, survival and differentiation. Two papers in this issue of Oncogene (Cheli et al …